Although the human brain represents only 2% of adult body mass, it requires 20% of resting metabolic rate (Phillips et al., 2016). With almost no energy stores, this high cerebral energy demand comes at a cost of a constant supply of metabolites. Unsurprisingly, the brain receives 15% of the total cardiac output and is highly reliant on the proper functioning of the heart (Willie and Smith, 2011). The catastrophic consequence of sudden cessation of blood flow to the brain manifests as stroke; however, subtler cerebral blood flow (CBF)

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The absence of the effect of CPT on VEFR in migraine is likely to be a consequence of impaired subcortical modulation of neurovascular coupling.

Changes in cerebral blood flow are one of the main features of migraine attack and have inspired the vascular theory of migraine. This traditional view has been reshaped with recent experimental data, which gave rise to the neural theory of migraine. In this review, we speculate that there might be an important link between the two theories, that is, the dysfunction of neurovascular coupling.