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Atopic dermatitis influences the psychological, neurological and social spheres, involving the patient, family and school because it generates symptoms that interfere negatively in the child's life. Objective: to identify the influence of atopic dermatitis on the child's life. Methodology: the searches were carried out in two bibliographic databases - PubMed and Scielo. Articles written in English and Portuguese, published from January 1985 to December 2016, were selected, related to: atopic dermatitis in the age group from 0 to 16 years. Results: children with atopic dermatitis develop less general daily activities than children without the pathology, as well as, have difficulty being alone, cry excessively, are more nervous, irritated, unhappy, more worried, insecure and have low self -esteem. Research has shown that the number of children who reported sleep interference is high and that the prevalence of attention deficit disorder, hyperactivity, anxiety, depression, conduct disorders and autism has been significantly increasing in children with atopic dermatitis. Conclusions: atopic dermatitis is a socially and psychologically relevant dermatosis, involving the patient, family and school in factors that, if not worked properly, generate considerable future consequences in the neurological, psychological and social spheres, harming the child's well-being and development.

RATIONALE: Penicillin is reported as a drug allergy in 10% of the general population. We studied the epidemiology of documented penicillin allergy in patients entering the ED of an inner-city tertiary care hospital including the general prevalence, prevalence by race, and reports of multiple drug allergies, defined as 2 or more allergies. METHODS: This was a retrospective review of patients entering the ED of University Hospital from 01/2017-07/2017. We identified all patients with a documented penicillin allergy by a query of the electronic medical record, removing duplicate presentations for the same patient. The total number of patients presenting to the ED over the same time frame was identified. Excel sheet filters were used to tally the number of patients with penicillin allergy, the number of African Americans and Whites with penicillin allergy, and the number of patients with multiple drug allergies. RESULTS: Of 7291 patients presenting the ED from 01/2017 to 07/2017, 2503 (34%) had documented penicillin allergy. Penicillin allergy was documented in 45% (1390/3043) of African American patients. Similarly 46% (385/832) of White patients had documented penicillin allergy. Twenty-eight percent (701/2503) of patients with penicillin allergy also reported allergy to multiple drugs. CONCLUSIONS: The prevalence of documented penicillin allergy is greater in our inner-city tertiary care hospital than in the general population (34% versus 10%). Prevalence in the African American and White population is approximately equal, but greater than the general population. Patients with penicillin allergy are likely to report allergies to two or more drugs.

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RATIONALE: Eosinophilic Esophagitis (EoE) is a condition with an increasing frequency, i ts relevant studying natural evolution of allergic diseases, considering EoE as a part of these conditions METHODS: We performed a retrospective analysis of 71 EoE patients. The objective was to describe the frequency of atopies and IgE mediated food allergy. We evaluated demographics, EoE family history, symptoms onset, diagnosis age, IgE aeroallergen and food sensitization RESULTS: We found diagnosis mean of age was 18 yo (5-78 yo). Time between symptoms onset and EoE diagnosis was 2.86 years. We found male predominance 48/71 (67.70%). The most prevalent atopy was allergic rhinitis (49/71-69.01%), IgE-mediated food allergy (39/71-54.92%), allergic asthma (29/71-40.84%) and atopic dermatitis (12/71-16.90%). Between IgE-mediated food allergy patients, 71.79% presents anaphylaxis history. Eleven patients (15.49%) only have EoE. IgE food sensitization (26/71-36.61%) was more frequent than aeroallergen (5/71-7.04%), being 27 patients (38.02%) with dual IgE sensitization (food and aeroallergen), 26 only food sensitization, 5 only aeroallergen sensitizations. Thirteen patients (18.30%) didn't have any IgE sensitization. About the relationship between food allergy and EoE evolution, found that patients with IgE food reactions preceded the diagnosis of EoE 38/39 (97.43%) CONCLUSIONS: We observed high prevalence of atopic conditions. Food IgE sensitization was important despite most of our patients were adolescents and adults. It's important to follow up food worsening EoE even in older patients. In most cases of IgE mediated food allergies, anaphylaxis history warns us about the possibility that atopic patients that developed EoE could be associated with severe food allergy phenotype RATIONALE: Eosinophilic esophagitis (EoE) is characterized by esophageal dysfunction with eosinophilic inflammation. Severe forms (fibrostenotic) are more frequently described in adults, due to the chronic, progressive evolution of the disease. We analyzed clinical, endoscopic, anatomopathological aspects of children with EoE. METHODS: Retrospective analysis (2001-2017) of 23 children, 0-16 years old (yo), followed-up at a Brazilian teaching hospital. RESULTS: 78,3% boys (n518), 4 yo [1. .83] at the onset of symptoms, 7.46 (SD64.28) yo when diagnosed. Symptoms: abdominal