Background Tranexamic acid reduces surgical bleeding and reduces death due to bleeding in patients with trauma. Meta-analyses of small trials show that tranexamic acid might decrease deaths from gastrointestinal bleeding. We aimed to assess the effects of tranexamic acid in patients with gastrointestinal bleeding. Methods We did an international, multicentre, randomised, placebo-controlled trial in 164 hospitals in 15 countries. Patients were enrolled if the responsible clinician was uncertain whether to use tranexamic acid, were aged above the minimum age considered an adult in their country (either aged 16 years and older or aged 18 years and older), and had significant (defined as at risk of bleeding to death) upper or lower gastrointestinal bleeding. Patients were randomly assigned by selection of a numbered treatment pack from a box containing eight packs that were identical apart from the pack number. Patients received either a loading dose of 1 g tranexamic acid, which was added to 100 mL infusion bag of 0•9% sodium chloride and infused by slow intravenous injection over 10 min, followed by a maintenance dose of 3 g tranexamic acid added to 1 L of any isotonic intravenous solution and infused at 125 mg/h for 24 h, or placebo (sodium chloride 0•9%). Patients, caregivers, and those assessing outcomes were masked to allocation. The primary outcome was death due to bleeding within 5 days of randomisation; analysis excluded patients who received neither dose of the allocated treatment and those for whom outcome data on death were unavailable. This trial was registered with Current Controlled Trials, ISRCTN11225767, and ClinicalTrials.gov, NCT01658124.

The Kish key distribution system has been proposed as a classical alternative to quantum key distribution. The idealized Kish scheme elegantly promises secure key distribution by exploiting thermal noise in a transmission line. However, we demonstrate that it is vulnerable to nonidealities in its components, such as the finite resistance of the transmission line connecting its endpoints. We introduce a novel attack against this nonideality using directional wave measurements, and experimentally demonstrate its efficacy.

This tutorial paper provides a short introduction to geometric algebra, starting with its history and then presenting its benefits and exploring its applications.

The Kish Key Distribution (KKD) system has been proposed as a classical alternative to quantum key distribution, making use of temperature-matched thermal noise. Previous analyses assume instant propagation of signals along the cable connecting the two users. We describe a new attack that takes an advantage of propagation delays. At the start of each bit period, the noise temperature will then be increased from zero to its final value. During this process, the noise temperature variation will take time to propagate along the line, resulting in a temperature mismatch. We analyze the information leak due to this effect and consider several potential mitigation schemes.

Parrondo's games manifest the apparent paradox where losing strategies can be combined to win and have generated significant multidisciplinary interest in the literature. Here we review two recent approaches, based on the Fokker-Planck equation, that rigorously establish the connection between Parrondo's games and a physical model known as the flashing Brownian ratchet. This gives rise to a new set of Parrondo's games, of which the original games are a special case. For the first time, we perform a complete analysis of the new games via a discrete-time Markov chain (DTMC) analysis, producing winning rate equations and an exploration of the parameter space where the paradoxical behaviour occurs.