In the history of modern science, nanotechnology accomplished the most attraction by the researchers as nanomaterials exhibit novel and significantly improved properties in term of physical, chemical, and biological properties and they can be modified accordingly. These are mainly because there is an increase in surface area as compared to volume as particles get smaller. Electrospinning is one of the most suitable method for producing continuous nanomaterials with varying physical, chemical and biological properties. In this review paper we discussed the theory and the experimental setup of electrospinning along with the history of this process. We also review on the effect of parameters (solution, processing and ambient) on the fiber morphology and the potential applications of electrospun nanofibers. This is followed by geometrical, chemical, physical and mechanical characterization procedure of electrospun nanofiber.

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International audienceFrom an engineering point of view, prediction of fatigue crack nucleation in automotive rubber parts is an essential prerequisite for the design of new components. We have derived a new predictor for fatigue crack nucleation in rubber. It is motivated by microscopic mechanisms induced by fatigue and developed in the framework of Configurational Mechanics. As the occurrence of macroscopic fatigue cracks is the consequence of the growth of pre-existing microscopic defects, the energy release rate of these flaws need to be quantified. It is shown that this microstructural evolution is governed by the smallest eigenvalue of the configurational (Eshelby) stress tensor. Indeed, this quantity appears to be a relevant multiaxial fatigue predictor under proportional loading conditions. Then, its generalization to non-proportional multiaxial fatigue problems is derived. Results show that the present predictor, which is related to the previously published predictors, is capable to unify multiaxial fatigue data

Polyglycolic acid (PGA) is a class of semicrystalline, bioresorbable polymers that have been widely used in a number of applications. No other bioresorbable materials can fully replace PGA in tissue engineering. Understanding degradation mechanisms in PGA is important for improving the efficiency and effectiveness in various fields including implantation. This review begins with a discussion on terminology of polymer degradation and hydrolytic degradation mechanism with a delineative model. This review also focus on previous degradation studies taking advantage of its fast-degrading behavior and the mechanism behind hexafluoroisopropanol (HFIP) being the sole solvent for PGA. Finally, the merits of PGA are discussed with many potential future applications along with their associated challenges.

The key attributes of core–shell fibers are their ability to preserve bioactivity of incorporated-sensitive biomolecules (such as drug, protein, and growth factor) and subsequently control biomolecule release to the targeted microenvironments to achieve therapeutic effects. Such qualities are highly favorable for tissue engineering and drug delivery, and these features are not able to be offered by monolithic fibers. In this review, we begin with an overview on design requirement of core–shell fibers, followed by the summary of recent preparation methods of core–shell fibers, with focus on electrospinning-based techniques and other newly discovered fabrication approaches. We then highlight the importance and roles of core–shell fibers in tissue engineering and drug delivery, accompanied by thorough discussion on controllable release strategies of the incorporated bioactive molecules from the fibers. Ultimately, we touch on core–shell fibers-related challenges and offer perspectives on their future direction towards clinical applications.