Expression of p53 and Bcl-2 in locally advanced infiltrating ductal carcinoma of the breast. Its relationship with the intrinsic molecular subtype as a prognostic factor.

The Ki-67 index is a biomarker that indicates the proliferation of cancer cells and is considered an effective prognostic factor for breast cancer. However, a standard cut-off point has not yet been established for the Ki-67 index in triple negative breast carcinomas. Therefore, the objective of this retrospective study was to determine an optimal cut-off point to establish it as a more accurate prognostic factor in the triple negative molecular subtype. The immunohistochemical analysis of the Ki-67 index was performed in 98 patients with breast cancer. The survival study using the Kaplan-Meier method was used to analyze the factors related to overall survival. The cut-off points (20 and 25%) were selected from the univariate analysis because they had the highest Hazard ratio to perform the multivariate analysis. With statistical significance (p<0.001), the analysis revealed that in this series the optimal cut-off point of Ki-67 is 25%, with an independent value regarding the clinicopathological variables considered in the study. These data suggest that the optimal cut-off point at 25% is a more effective prognostic factor for triple negative phenotype breast cancer. Due to the importance of these findings, it is recommended to verify the prognostic value of Ki-67 25% in series with a greater number of patients.