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Background. Breast cancer (BC) is the first cause of cancer morbidity and mortality in women. This disease has been linked to obesity; however, it is not clear how fat accumulation affects women who survive breast cancer. Although the visceral adiposity index (VAI) is a marker of cardiometabolic risk and adipose tissue dysfunction, it is not clear how it changes in breast cancer survivors. The aim of this investigation was to compare VAI in women with and without breast cancer. Methods. A case-control cross-sectional study was conducted on women who were BC survivors and women without the history of BC (control group). Body composition was assessed using electrical bioimpedance while VAI by means of waist circumference (WC), body mass index (BMI), triacylglycerols (TG), and high-density lipoprotein cholesterol (HDL-C). Results. 49 women in the BC survivor group and 50 in the control group. WC was wider in the survivor group as regards control (93.65 ± 10.48 vs. 88.52 ± 9.61 cm) ( p = 0.025 ); at once, TG and VAI were significantly higher for the survivor group (243.55 ± 199.84 vs. 159.84 ± 75.77) ( p = 0.007 ) and (11.03 ± 11.15 vs. 6.41 ± 3.66) ( p < 0.005 ), respectively. Body composition parameters were similar in both groups. Conclusions. VAI is higher in women who are BC survivors in comparison with controls matched by age and bodyweight.

Breast cancer and obesity are two diseases that currently occur in a high percentage of women population. Central obesity is an important risk factor for developing breast cancer. Both obesity and cancer are characterized by a chronic state of inflammation in part maintained by cytokines secreted by fat tissue; however, it is not clearly known how they are linked to each other. The aim of this study was to compare body composition and visceral adiposity index (VAI) between women with and without breast cancer. The participants included women 40–60 years old, with stages I and II of breast cancer, who voluntarily accepted to participate in the study. The control group comprised women with BIRADS 1, 2 and 3 mammograms, and the same age span. General sociodemographic data, hereditary family history of breast cancer, gyneco‐obstetric history and histopathological classification of breast cancer were recorded for each participant. Additionally, body composition was evaluated with electrical bioimpedance using an InBody230 equipment. In order to compute the VAI, concentrations of triacylglycerols and high‐density lipoproteins cholesterol (HDL‐c) were measured by colorimetric tests. Data were analyzed using Mann‐Whitney test. The results showed that women with breast cancer presented a higher mean of body mass index (BMI) than the control group (30.4 ± 3.8 Kg/m2 vs 26.5 ± 2.6 Kg/m2, respectively); but these were not significant different (p=.99). The VAI in women with breast cancer was 4.5 ± 0.8, but in the control group was 3.9 ± 0.5; however they were not significantly different. In summary, women with breast cancer showed a higher BMI and VAI, which suggests these markers of obesity might be useful in the diagnostics procedures for this type of cancer, but further analysis in a bigger population is required.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.