Tumor metastasis is a leading cause of cancer-related death. Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase recruited to integrin-mediated matrix attachment sites where FAK activity is implicated in the control of cell survival, migration, and invasion. Although genetic studies support the importance of FAK activity in promoting tumor progression, it remains unclear whether pharmacological FAK inhibition prevents tumor metastasis. Here, we show that the FAK inhibitor PND-1186 blocks FAK Tyr-397 phosphorylation in vivo and exhibits anti-tumor efficacy in orthotopic breast carcinoma mouse tumor models. PND-1186 (100 mg/kg intraperitoneal, i.p.) showed promising pharmacokinetics (PK) and inhibited tumor FAK Tyr-397 phosphorylation for 12 hours. Oral administration of 150 mg/kg PND-1186 gave a more sustained PK profile verses i.p., and when given twice daily, PND-1186 significantly inhibited sygeneic murine 4T1 orthotopic breast carcinoma tumor growth and spontaneous metastasis to lungs. Moreover, low-level 0.5 mg/ml PND-1186 ad libitum administration in drinking water prevented oncogenic KRAS- and BRAF-stimulated MDA-MB-231 breast carcinoma tumor growth and metastasis with inhibition of tumoral FAK and p130Cas phosphorylation. Although PND-1186 was not cytotoxic to cells in adherent culture, tumors from animals receiving PND-1186 exhibited increased TUNEL staining, decreased leukocyte infiltrate and reduced tumor-associated splenomegaly. In vitro, PND-1186 reduced tumor necrosis factor-α triggered interleukin-6 cytokine expression, indicating that FAK inhibition may impact tumor progression via effects on both tumor and stromal cells. As oral administration of PND-1186 also decreased experimental tumor metastasis, PND-1186 may therefore be useful clinically to curb breast tumor progression.

Questions about people's pasts are common in many surveys, but memories are error prone. The current research focuses on recall failures in the American Time Use Survey (ATUS). The ATUS most commonly encourages respondents to report all of their activities of the previous day in a forward chronological fashion, from the beginning to the end of the day. Even with a short reference period, the ATUS is prone to recall errors. We explore these errors taking into account the response process, respondent, and interviewer as possible contributors to a recall failure. Importantly, we posit that the chronological recall of events leads to earlier activities affecting recall of the current activity. Events are more easily recalled when they are more distinct (less frequent) or additional contextual information about the event is available. While research has focused on these characteristics of the target event, the previous event recalled may also provide distinctiveness and context. Results suggest that periods following a more frequent activity are likely to be followed by a failure, although this is modulated by the duration of the event. The presence of others and places of the event also have significant effects. The elapsed time since the event is also important, with a higher chance of recall failure for more distant activities. Although results highlight the importance of the response-level in understanding outcomes, respondent characteristics still matter, as those with apparently lower cognitive ability are more likely to have a failure. Interviewers also contribute to the variance of recall failures, with interview experience not having an apparent effect, while interviewers who make other types of errors, surprisingly, show lower likelihoods of recall failure. The results shed light on the relationship between memory and survey errors, and suggest implications for future survey design.

<p class="MsoNoSpacing" style="text-align: justify; margin: 0in 0.5in 0pt;"><span style="font-size: 10pt;"><span style="font-family: Times New Roman;">A shift from male-majority to female-majority university campuses has opened up new areas for research on gender bias, stereotypes, and discrimination. At one large state university on the west coast, there were more female than male graduates in Spring, 2008 in 7 out of 8 colleges, including the traditionally male-majority areas of business and science.<span style="mso-spacerun: yes;">&nbsp; </span>Relative probabilities for men and women of receiving honors in each major field of study at this school, compared to national data of gender breakdowns by field in 1980, showed that men and women were still relatively more likely to receive honors in fields that were traditionally male and female, respectively. Findings also cast doubt upon Kanter&rsquo;s tokenism hypothesis. Curiously, it was traditionally female, not male, fields that had the highest levels of gender inequity, though gender inequity overall may be on a decline. More research is needed to identify why this difference between gender and honors still exists. Universities should also be aware of the continuing potential for subtle gender discrimination, even in fields where equal numbers of men and women participate.</span></span></p>

In interviewer-administered omnibus surveys, burdensome questions asked early in a survey may result in lower quality responses to questions asked later in a survey. Two examples of these burdensome questions are social network questions, wherein respondents are asked about members of their personal network, and knowledge questions, wherein respondents are asked to provide a factually correct response to a question. In this study, we explore how the presence of potentially burdensome questions are associated with item nonresponse and acquiescence rates on subsequent survey questions, and whether this effect differs by respondent age and education. We use data from the 2010 General Social Survey (AAPOR RR5 ¼ 70.3%, AAPOR 2016), which experimentally varied the location of a social network module and the presence of a knowledge question module. Those who received knowledge questions had higher item nonresponse rates on subsequent questions than those who did not receive knowledge questions, but the quality of responses did not differ by the presence of social network questions. Further, respondents with different characteristics were not differentially burdened by the knowledge questions or the social network questions. We conclude that knowledge questions may be better asked near the end of omnibus surveys to preserve the response quality for subsequent questions.