Asam urat yang berlebihan tidak akan tertampung dan termetabolisme seluruhnya oleh tubuh, sehingga akan terjadi peningkatan kadar asam urat dalam darah yang disebut sebagai perurisemia. Gangguan asam urat ditandai dengan suatu serangan tiba-tiba di daerah persendian. Nyeri yang timbul pada umumnya muncul secara tiba-tiba. Kemunculan secaratiba-tiba ini sering menyebabkan penderita asam urat sulit bergerak. Tujuan penelitian ini adalah untuk menguji efektivitas pemberian rebusan daun sirsak terhadap penurunan kadar asam urat pada lansia wanita penderita Gout Artritis. Desain penelitian ini menggunakan rancangan penelitian dengan metode analitik (Pra ex. Design one group pre-post test design). Sampel penelitian ini adalah lansia wanita penderita gout artrhitis di Kecamatan Lawangan Daya sebanyak 14 responden. Pengambilan data menggunakan lembar observasi, hasil pengujian kadar asam urat dianalisis dengan uji statistik Paired T Test menggunakan SPSS. Hasil penelitian menunjukkan P<0.05 artinya terjadi penurunan yang signifikan dari pemberian rebusan daun sirsat terhadap kadar asam urat Lansia Wanita penderita Gout Artritis di Kelurahan Lawangan Daya Kabupaten Pamekasan. Melihat hasil penelitian ini diperlukan pemberian rebusan daun sirsak secara rutin. Kesimpulan dari penelitian ini adalah pemberian rebusan daun sirsak terbukti efektif dapat menurunkan kadar asam urat pada penderita Gout Artrhitis. Rebusan daun sirsak dapat dijadikan obat herbal yang tidak memiliki efek samping bagi penderita atau responden.    Kata Kunci : Lansia wanita, daun sirsak, Gout Artritis.

Exopolysaccharides get a lot of attention because they can improve the host immune system. Exopolysaccharide is a polysaccharide that is produced and secreted from microbes outside the cell, usually found on the outside of the bacterial structure. The Lactobacillus casei group from human breast milk is thought to have the ability to produce exopolysaccharides. The purpose of the study was to examine the exopolysaccharide of the L. casei group that was isolated from breast milk. The methods used include the gravimetric, the phenol-sulfuric acid and the Fourier Transform Infra-Red (FTIR). The results showed that the L. casei group could produce exopolysaccharides, and had high exopolysaccharide total sugar content. Lactobacillus paracasei had the highest exopolysaccharide and total sugar content of 3660 mg/L and 80.6%, respectively. The FTIR results of the L. casei group exopolysaccharides showed the presence of hydroxyl functional groups O-H (3425.76-3295.98 cm-1), methyl C-H (2930.86-2856.70 cm-1), carbonyl C=O (1660.11-1647.27 cm-1), C-H (1456.16-1373.44 cm-1) and C-O-C ether (1071.08-1056.82 cm-1) which are specific characters of exopolysaccharides. Since the FTIR profile demonstrates that the L. casei group can produce exopolysaccharides, it has greater potential as a a probiotic.

Obesity and hyperglycemia can trigger various diseases, including diabetes mellitus and cardiovascular ailments. Health-promoting fermented milk products can be useful in tackling these issues. One such product is the fermented milk developed using Lactobacillus casei AP, a probiotic strain from Indonesia that has not been tested in humans thus far. Our objective was to examine the effects of L. casei AP-fermented milk products on lipid profiles, blood glucose levels and monocyte chemoattractant protein-1 (MCP-1) levels in obese adults. A total of 29 obese subjects were given L. casei AP-fermented milk products, and their fasting blood glucose, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride levels were measured using diagnostic system kits. MCP-1 levels were measured using enzyme-linked immunosorbent assay. It was determined that the administration of L. casei AP-fermented milk products significantly reduced total cholesterol, LDL and triglyceride levels (p &lt; 0.05); however, it did not increase HDL (p &gt; 0.05), MCP-1 or fasting blood glucose levels (p &ge; 0.05). In conclusion, in obese Indonesian adults, L. casei AP-fermented milk might reduce total cholesterol, LDL and triglyceride levels but may not affect HDL, MCP-1 or fasting blood glucose levels.

Introduction: people who suffer from stroke and immobilization use wheelchair to help move/carry out daily activities on average, so they may be at risk of falling during its usage. This research aimed to comprehend the fall risk assessment in stroke clients with wheelchair at RSUD Dr. H. Slamet Martodirdjo Pamekasan. Methods: This research used a cross sectional descriptive design. Population in this research was 31 stroke clients using wheelchairs in Pamekasan District with the sampling technique using total sampling. This research was conducted in the region of Pamekasan on February, 2021. Data was collected by distributing a Close ended-Multiple choice questionnaire with an ordinal scale containing of 12 question items and then processing the data in the form of editing, scoring, tabulating. Results: Most of the total respondents who have been researched indicate a low risk of falling as 14 people (45%). Conclusion: The Families are expected to provide assistance and supervision to stroke client, especially those who have experienced falling.

Imobilisasi lama di atas kursi roda dapat memberikan dampak negatif akibat penggunaan kursi roda yang lama salah satu dampak negatif yang terjadi yaitu ulkus dekubitus, nyeri sendi dan atropi. Pemilihan desain kursi roda juga memiliki peranan penting untuk mencegah dampak negatif imobilisasi. Tujuan penelitian ini untuk mengetahui pengembangan kursi roda yang efektif dalam menurunkan dampak negatif imobilisasi lama pada penyandang disabilitas fisik dengan kelumpuhan. Desain penelitian ini menggunakan systematic review yaitu membaca dan mentelaah dari beberapa artikel penelitian sebelumnya tentang pengembangan kursi roda dalam menurunkan dampak negatif imobilisasi lama. Pengembangan kursi roda yang bertujuan untuk mengurangi dampak negatif akibat imobilisasi lama pada penyandang disabilitas fisik dengan kelumpuhan meliputi penambahan komponen mekanisme sandaran yang  portabel, pengaturan ketinggian arm rest, pengatur ketinggian foot rest dan footcycling. Pengembangan kursi roda dengan memperhatikan desain ergonomis dan komponen tambahan exercise memiliki peranan penting untuk memberikan keamanan dan kenyamanan dalam penggunaan kursi roda khususnya untuk mencegah timbulnya dampak negatif imobilisasi pada penyandang disabilitas fisik dengan kelumpuhan.