Objective The objective of this study was to determine the characteristics of demineralized dentin material sponge (DDMS).
Material and Methods An observational study was conducted on DDMS and BPCM. Fourier transform infrared (FTIR) test was performed to determine the characterizations of the materials. Scanning electron microscope-electron dispersive X-ray spectroscopy (SEM-EDX) test was performed to observe the elements contained in the materials.
Results The infrared spectrum of the DDMS and BPCM functional groups showed the same pattern in each variation, and no significant differences were found. According to SEM analysis, the cavities that make up the membrane were spotted on the surface. Besides, according to the SEM-EDX analysis, DDMS contained chlorine, carbon, and calcium, while BPCM contained carbon, oxygen, and sulfur.
Conclusion DDMS has the potential to be a biomaterial for bone tissue engineering in terms of the characteristics. DDMS had a structure that almost resembles BPCM as seen from the results of the FTIR graph between DDMS and BPCM. The morphological structure of the two materials in the SEM test appeared to have porosity with various sizes.
Cancer is a disease caused by uncontrolled cell growth. Cancer treatments, such as chemotherapy, have tended to cause adverse effects for patients. An alternative that can be described is the development of natural-based cancer therapies that have relatively low side effects. The development of Na-alginate as a matrix for nanoencapsulation of Uncaria gambir has shown growth inhibition activity against HeLa and T47D cell lines. The EC50 ± SE of U. gambir extract on the HeLa cell line was 1055.14 ± 42.52 µg/mL while on the T47D cell line 297.15 ± 15.41 µg/mL. On the other hand, the Ug-NPs anticancer activity was substantially higher with EC50 ± SE for HeLa cell line 28.12 ± 27.10 µg/mL, and T47D cell line 10.39 ± 3.50 µg/mL. Therefore, the nanoencapsulation of U. gambir extracts has increased solubility, selectivity, and activity.
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