The asymmetric synthesis of protected 2-amino-1,3-diols (S,R)-5 starting from 2,2-dimethyl-1,3-dioxan-5-one is described. The stereogenic centres are generated by α-alkylation using the SAMP/RAMP hydrazone methodology and diastereoselective reduction of the ketones (S)-2 with Lselectride. The resulting alcohols (S,S)-3 are converted into the amines (S,R)-4 by nucleophilic substitution with sodium azide and subsequent reduction with lithium aluminium hy-
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