In view of the overall health impact of NIDDM, inventers understand the necessity of improving glycemic control in adults with type 2 diabetes. BGR-34 provides an effective treatment option for adults with type 2 diabetes who have been inadequately controlled on lifestyle with or without other oral hypoglycemic agents (OHGAs) such as metformin, sulfonylurea, or a glitazones. BGR-34 is an appropriate option to consider for addition to a managed care drug formulary. Treatment with BGR-34 produced clinically relevant and statistically significant reductions in all three key measures of glucose control studied —FPG, PPBG and HbA1c— when compared with placebo. BGR-34, showed the promising result with respect to glycemic parameters in NIDDM patient with a significant reduction in fasting blood sugar by 34.3%, postprandial blood sugar 35.5% & glycosylated haemoglobin by 20.31% as compared to placebo group showing a reduction by 13.2%, 10.9% & 10.87% respectively. The trial has also been registered to CTRI, India. This study has been registered in the clinical trial registry-India.

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Background and Aims: Subarachnoid block (SAB) using Bupivacaine lacks postoperative analgesia. Aim of present study was to assess safety and efficacy of 50 µ and 100µ intrathecal Neostigmine for postoperative analgesia. Materials and Methods: Ninety patients of age 18 to 65 were allocated randomly to three groups of 30 each and studied prospectively by double blind controlled trial. Patient posted for lower limb and lower abdominal surgeries were given SAB using 3 ml Bupivacaine 0.5% in group A, 2.9 ml Bupivacaine + 50 µ Neostigmine in B and 2.8 ml Bupivacaine and 100µ Neostigmine in C. Patients were monitored for onset, regression of sensory and motor block, blood pressure and heart rate. Postoperatively patients were assessed for pain score using visual analogue scale (VAS) and duration of analgesia by rescue analgesia requirement. Results: 90 patients enrolled were analysed. VAS pain score was more in group A compared to B which had higher than group C. Analgesia was prolonged in group C than in B which had better analgesia than group A. Incidence of nausea, vomiting and bradycardia was higher with 100µ Neostigmine than 50 µ. Conclusion: Intrathecal Neostigmine 50 µ dose as an adjuvant to Bupivacaine is associated with good postoperative analgesia and hemodynamic stability while 100 µ dose was associated with more prolonged analgesia and higher incidence of adverse effects.

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The Coronavirus Disease 2019 started in Wuhan Province, China and which spread to half a dozen countries between 2019 and 2020 and was declared a pandemic. This resulted in the implementation of a lockdown in different parts of the world, explaining it was an effective and essential way to break the cycle of infection. Physical distancing is the most important measure to break this infection cycle which affected many people's lives in different aspects. Mental health is considered to be one of the important components of the overall health as the definition given by the World Health Organization. It says that the person should be well-adjusted with the environment and should not be easily upset. He should know his needs, problems and goals properly; moreover, if he faces problems, he tries to solve them intelligently for which he tries to cope up with stress and anxiety. Along with all these things, he has good self-control balances between rationality and emotionality. It has likewise set off a wide variety of mental issues, for example, anxiety, panic disorder and depression. Most of the studies have reported negative impacts, including anger, stress symptoms and confusion. Education and training on pandemic should be provided by the authorities and health care workers.