The implementation of conditional cash transfer gets a serious attention from a number of developed countries as an effective approach to cut poverty and increase long-term social investment for the poor family. However, in terms of multicultural social community, the implementation of Program Keluarga Harapan (Hope Family Program) gives a little attention to the local culture-based sensitivity. This research focuses on the enforcement of local culture-based Hope Family Program in South Jayapura district. This research aims to analyze the implementation of PKH and to determine a local culture-based program implementation. The research design selected was a sequential explanatory design by applying random sampling and purposive sampling technique. Data analysis is emphasized by a qualitative-descriptive analysis. This research result reveals that the implementation of local culture-based Hope Family Program never fully considered the cultural sensitivity of the poor family even though 10% of the poor family of Hope Family Program beneficiary has said to consider that local cultural sensitivity. This conclusion emphasizes that the implementation of conditional cash transfer assistance to the local culture-based poor family truly influences the achievement of program purpose in a dominant community of socio-culture. Thus, technically, the aspect of cultural competence and cultural sensitivity is important to pay attention to the organization of program implementation.

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