Creating systems for targeted delivery of drugs to the affected organ is one of the most promising areas for the development of systems with controlled release of the active substance. Polysaccharides are widely used as drug carriers. However, most of them are chemically inert and require preliminary functionalization in order to interact with physiologically active compounds (therapeutic agents-TA). A simple and effective method for introducing reactive groups is the periodic oxidation of the polysaccharide by the Malaprade reaction. While cellulose is insoluble in water and resistant to weak solutions of acids and alkalis, dialdehyde cellulose (DAC is the product of the periodic oxidation of cellulose) and its derivatives are destroyed in water and weakly acidic and slightly alkaline solutions. This process is called hydrolytic destruction. The kinetics of hydrolytic destruction is described by semi-logarithmic anamorphosis, which allows us to calculate the rate constants of hydrolytic destruction as the rate constant of first-order reactions. The products of hydrolytic degradation were studied by UV spectroscopy and using 3,5-dinitrosalicylic acid (DNSA). The degradation products of C and DAC were also studied by the phenol-sulfur method. From the data presented and cited earlier, it follows that when our composite material is placed in a liquid medium, the hydrolytic destruction of the drug immediately begins. What can be connected with the breakdown of both the carrier – TA bonds (DAC, C, Ct carriers) and the destruction of the carrier itself. Under the conditions of the organism, biological destruction can also join process. Biodestruction is the process of destruction (both carriers and immobilized TAs) under the action of the body's enzymes. Using IR spectroscopy, cellulose carriers were studied before and after exposure to 1/15M FB medium (pH 6.2 and 37 °C) for 48 hours. As can be seen from the data obtained, primarily for DAC samples, significant changes in the spectrum are visible in the 1800-1600 and 900 cm-1 fields. The results of experimental toxicological studies of samples of various cellulosic materials allow us to conclude that the samples studied do not have toxic, hemolytic, allergenic effects, as well as mutagenic activity.

One of the high-potential areas in the search for new medical materials was the study, creation and introduction into practice of materials based on chitosan (Ct). The unique complex of Ct properties, such as biocompatibility, biodegradability, non-toxicity against the background of high biological and sorption activity, makes it possible to attribute this aminopolysaccharide to a tiny group of industrially available, environmentally safe polymers and, to potentially new biomaterials based on it, extremely suitable for medical use. Ct rapidly undergoes biodegradation under the action of enzymes of a living organism, without forming toxic substances. Therefore, it can become an excellent biodegradable protective material for the treatment of open wounds and burns. The enzyme-containing chitosan materials – which are advisable to use at the stage of cleansing the wound from necrotic tissue and in the cosmetic therapy of keloid scars – are of exceptional interest. At the same time, it is possible in principle to control the speed of biological and hydrolytic degradation of materials on the wound surface. Due to its positive charge in acidic and neutral environments, chitosan has bioadhesiveness, bactericidal effect and promotes wound healing, absorbs biological fluids and helps tissue regeneration. Immobilization in chitosan gel, drying and storing various therapeutic agents and their mixtures in different directions affects the properties of the immobilized drug and its biological activity.