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One of the high-potential areas in the search for new medical materials was the study, creation and introduction into practice of materials based on chitosan (Ct). The unique complex of Ct properties, such as biocompatibility, biodegradability, non-toxicity against the background of high biological and sorption activity, makes it possible to attribute this aminopolysaccharide to a tiny group of industrially available, environmentally safe polymers and, to potentially new biomaterials based on it, extremely suitable for medical use. Ct rapidly undergoes biodegradation under the action of enzymes of a living organism, without forming toxic substances. Therefore, it can become an excellent biodegradable protective material for the treatment of open wounds and burns. The enzyme-containing chitosan materials – which are advisable to use at the stage of cleansing the wound from necrotic tissue and in the cosmetic therapy of keloid scars – are of exceptional interest. At the same time, it is possible in principle to control the speed of biological and hydrolytic degradation of materials on the wound surface. Due to its positive charge in acidic and neutral environments, chitosan has bioadhesiveness, bactericidal effect and promotes wound healing, absorbs biological fluids and helps tissue regeneration. Immobilization in chitosan gel, drying and storing various therapeutic agents and their mixtures in different directions affects the properties of the immobilized drug and its biological activity.

One of the important directions in the field of creation and research of medicines is the optimization of the therapeutic action of the active substance and the study of the interaction of the drug and its components with the body. Numerous studies have established that a modern wound-healing agent should have the following properties: to sorb purulent discharge and its destruction products, to have cleansing properties (usually due to the introduced proteolytic enzyme), to have biocidal properties (especially with respect to pathogenic microflora and first of all with respect to to Staphylococcus aureus), because wound infection can significantly slow down the healing process, and in some cases contribute to the transition of the wound process to a chronic one and include an antioxidant (especially for the treatment of long-term diseases). The degradation of high-molecular compounds in the body can be biological and non-biological. From the point of view of the destruction of biopolymers, degradation under the influence of external factors existing in the environment of a living organism is of particular interest. The mechanism for the release of a therapeutic agent into a wound occurs due to the destruction of the base and the rupture of various links between the therapeutic agents and the matrix during its use: hydrolytic destruction under the action of the body environment, as well as biological destruction due to the action of various biomolecules in the medium, mainly enzymes. On the basis of our own and literature data, schemes have been proposed for working in a model liquid medium of wound applications, based on dialdehydecellulose and chitosan, containing immobilized therapeutic agents, including enzymes. Chitosan has been shown to stabilize dialdehyde cellulose during hydrolytic degradation. Immobilization in chitosan gel, drying and storing various therapeutic agents and their mixtures in different directions affects the kinetics of drug release.