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The present paper discusses the results of an analysis of the impact of land use on the distribution of pharmaceuticals in groundwater samples collected during a pilot study of the contents of pharmaceuticals and hormones in ground-water taken from the national groundwater monitoring network of the Polish Geological Institute - National Research Institute. Samples were collected during monitoring campaigns from 160 groundwater monitoring sites in various land use types in 2016 and 2017. Samples were analysed for a total of 34 active substances, including natural and synthetic oestrogen hormones, cardiovascular and respiratory medications, analgesics and anti-inflammatories, antidepressants, antimicrobial drugs and anti-epileptics. Our study confirmed the presence of pharmaceuticals in 53 per cent of ground-water samples taken. Data show variations in the distribution of pharmaceuticals depending on land use type, which can thus be employed in pressure analysis and identification of sources of pollution.

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Microsatellite instability (MSI) is a molecular landmark of mutations in DNA mismatch repair genes. The impaired efficiency of DNA repair mechanisms promotes carcinogenesis as well as contributes to tumour progression. Until now, only few studies on MSI in thyroid tumours have been published. Therefore, the aim of the present study was to investigate MSI as a possible characteristic feature of thyroid tumours. The analysis of 12 thyroid papillary carcinomas and 17 multinodular hyperplasias at 13 microsatellite loci showed MSI and loss of heterozygosity (LOH) in both types of lesion, with more alterations noted in the papillary thyroid carcinomas (in 65%) than in multinodular hyperplasia (in 35%). In carcinomas, LOH occurred more frequently than MSI, while in multinodular hyperplasia the LOH/MSI ratio is almost equal.