SUMMARYWe develop a three-dimensional ÿnite-deformation cohesive element and a class of irreversible cohesive laws which enable the accurate and e cient tracking of dynamically growing cracks. The cohesive element governs the separation of the crack anks in accordance with an irreversible cohesive law, eventually leading to the formation of free surfaces, and is compatible with a conventional ÿnite element discretization of the bulk material. The versatility and predictive ability of the method is demonstrated through the simulation of a drop-weight dynamic fracture test similar to those reported by Zehnder and Rosakis.1 The ability of the method to approximate the experimentally observed crack-tip trajectory is particularly noteworthy.

We develop a three‐dimensional finite‐deformation cohesive element and a class of irreversible cohesive laws which enable the accurate and efficient tracking of dynamically growing cracks. The cohesive element governs the separation of the crack flanks in accordance with an irreversible cohesive law, eventually leading to the formation of free surfaces, and is compatible with a conventional finite element discretization of the bulk material. The versatility and predictive ability of the method is demonstrated through the simulation of a drop‐weight dynamic fracture test similar to those reported by Zehnder and Rosakis. The ability of the method to approximate the experimentally observed crack‐tip trajectory is particularly noteworthy. © 1999 John Wiley & Sons, Ltd.

Using basic physical arguments, we present a design and method for the fabrication of microfluidic valves using multilayer soft lithography. These on-off valves have extremely low actuation pressures and can be used to fabricate active functions, such as pumps and mixers in integrated microfluidic chips. We characterized the performance of the valves by measuring both the actuation pressure and flow resistance over a wide range of design parameters, and compared them to both finite element simulations and alternative valve geometries.

Experimental tests on human corneas reveal distinguished reinforcing collagen lamellar structures that may be well described by a structural constitutive model considering distributed collagen fibril orientations along the superior-inferior and the nasal-temporal meridians. A proper interplay between the material structure and the geometry guarantees the refractive function and defines the refractive properties of the cornea. We propose a three-dimensional computational model for the human cornea that is able to provide the refractive power by analyzing the structural mechanical response with the nonlinear regime and the effect the intraocular pressure has. For an assigned unloaded geometry we show how the distribution of the von Mises stress at the top surface of the cornea and through the corneal thickness and the refractive power depend on the material properties and the fibril dispersion. We conclude that a model for the human cornea must not disregard the peculiar collagen fibrillar structure, which equips the cornea with the unique biophysical, mechanical, and optical properties.

The human cornea (the external lens of the eye) has the macroscopic structure of a thin shell, originated by the organization of collagen lamellae parallel to the middle surface of the shell. The lamellae, composed of bundles of collagen fibrils, are responsible for the experimentally observed anisotropy of the cornea. Anomalies in the fibril structure may explain the changes in the mechanical behavior of the tissue observed in pathologies such as keratoconus. We employ a fiber-matrix constitutive model and propose a numerical model for the human cornea that is able to account for its mechanical behavior in healthy conditions or in the presence of keratoconus under increasing values of the intraocular pressure. The ability of our model to reproduce the behavior of the human cornea opens a promising perspective for the numerical simulation of refractive surgery.