Purpose Infections with carbapenem-resistant gram-negative bacteria (in Germany classified as 4MRGN) are a growing threat in clinical care. This study was undertaken to understand the overall burden of 4MRGN infections in Germany in the context of a Health Technology Appraisal (HTA) for Ceftazidime/Avibactam (CAZ/AVI). Besides, the incidences mortality was an endpoint of interest. Methods To assess infections with carbapenem-resistant gram-negative bacteria and related mortality, three different data sources have been used. From the German statistics office (DESTATIS) data have been retrieved to obtain the overall frequency these pathogens. Via two other databases, the German analysis database (DADB) and a Benchmarking of > 200 hospitals in a representative sample (BM-DB), the distribution of the infections and the mortality have been analyzed. Results DESTATIS data showed a total of 11,863 carbapenem-resistant gram-negative bacteria codings, of which 10,348 represent infections and 1515 carriers. The most frequent infections were complicated urinary tract infections (cUTI) (n = 2,337), followed by pneumonia (n = 1006) and intra-abdominal infections (n = 730). A considerable amount of patients had multiple infections in one hospital episode (n = 1258). In-hospital mortality was 18.6% in DADB and 14.3% in the BM-DB population, respectively. In cases with additional bloodstream infections, DADB mortality was correspondingly higher at 33.0%. DADB data showed an incremental mortality increase of 5.7% after 30 days and 10.0% after 90 days resulting in a cumulative 90 day mortality of 34.3%. Conclusions Infections with carbapenem-resistant gram-negative bacteria are still rare (6.8–12.4 per 100,000) but show a significant increase in mortality compared to infections with more sensitive pathogens. Using different data sources allowed obtaining a realistic picture.

A challenging aspect of the collection management process is effectively communicating with stakeholders about library resources.  Communication can range from obtaining patron feedback integral in collection planning to effective messaging elaborating on collection budgets and cancellation decisions.  It has also become increasingly necessary to explain the various acquisition models that affect the landscape of library content and use of electronic resources. In this paper, the University of South Florida will present the results of a survey of the approaches used in academic library websites to communicate collection policies along with related considerations, statistics and data, justifications, and factors affecting selection practices. Information about the important elements used to construct a dialog with faculty and administration in order to demonstrate the costs and value of library resources to those in the academic community is included. A case study demonstrating the practical implementation of these communication principles at the Arthur Lakes Library at the Colorado School of Mines will be discussed. The study will show how the Library was able to break free from a cycle of collection stagnation, which was perpetuated by a lack of effective communication. The result was that the Library was able to tell a story with data in order to communicate a message, as well as strengthen their partnerships with faculty regarding collection management.

Streaming media is prevalent, but it can be a daunting task for those in collection development and acquisitions to determine an appropriate way to provide access to it. This book is for those who have been hesitant to acquire streaming media or feel that they need to evaluate their current strategies regarding streaming media. The book’s stated purpose “is to address the logistics of providing steaming video for the library” (1). The book breaks down the key aspects into ten chapters and includes bibliographic references and an index.

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ZusammenfassungPatienten mit spastischer Bewegungsstörung (SMD) erhalten überproportional häufig keine leitliniengerechte Therapie. Daten der Gesundheitsforen Leipzig zur Prävalenz und Verordnung von Therapiemaßnahmen bei Patienten mit SMD (ICD-10) wurden mit den Verordnungen der von der Fachgesellschaft empfohlenen First-line-Medikation verglichen, um weitere Einblicke in die Versorgungsrealität von Patienten mit SMD zu erhalten. Es zeigte sich, dass innerhalb der deutschen GKV-Population jährlich über 700.000 Menschen (bzw. 830 je 100.000 Einwohner) mit einer SMD-Diagnose kodiert werden und es damit deutlich mehr Betroffene gibt, als zuvor berichtet. Von diesen erhält nur etwa 1% der Patienten eine leitliniengerechte medikamentöse Therapie.