Background Moderate alcohol consumption has been shown to protect against cardiovascular disease. Aortic stiffness can be regarded as a marker of cardiovascular disease risk. Previously we have shown an inverse to Jshaped association between alcohol intake and aortic stiffness in middle-aged and elderly men and postmenopausal women.Objective In the present study we examined whether a relation between alcohol intake and aortic stiffness is already present at a younger age.Design Cross-sectional data of a cohort study in men and women aged 28 years were analysed stratified by gender (240 men and 283 women).Measurements Alcohol intake was derived from a questionnaire and aortic stiffness was assessed by pulsewave velocity measurement. ResultsIn women an alcoholic beverage intake of !1 glass/day is associated with a 0.36 m/s (95% confidence interval, S0.58 to S0.14) lower pulse-wave velocity compared with non-drinkers. In men alcohol intake is also inversely related to pulse-wave velocity, but this was not significant. These findings were independent of age, blood pressure and heart rate.Conclusions These findings suggest that moderate intake of alcohol may affect vascular stiffness at an early age, notably in women. These findings may be viewed as compatible with a vascular protective effect of alcohol that expresses well before the occurrence of symptomatic cardiovascular disease.