Background: Poststroke global cognitive decline and dementia have been related to poor

No abstract

In patients with acute stroke, ARWMC seems to be a significant predictor of poor long term survival and death by ischaemic stroke.

Long-term follow-up of our large well-defined poststroke cohort indicated that in patients with acute stroke, dementia is a significant predictor of poor long-term survival and death from brain-associated causes. Prestroke cognitive decline seems to have an additional negative influence on survival, but previous stroke does not seem to affect survival.

Background and Purpose-Cerebral small vessel disease reflected by white matter lesions (WMLs) in MRI and kidney function reflected by estimated glomerular filtration rate (eGFR) is closely associated in patients without stroke. We studied whether eGFR and WMLs predict long-term survival in patients with acute stroke. Methods-After exclusion of patients with low eGFR (Nϭ5 [1.3%]; Ͻ30 mL/min/1.73 m 2 ), consecutive patients with acute stroke (Nϭ378) subjected to MRI and serum creatinine determination were included in the study and prospectively followed-up up to 12 years. Results-Of the patients, 71.2% had died during the follow-up, 152 (40.2%) had moderate (eGFR Ͻ60 mL/min/1.73 m