Thermophysical and bionotox properties of a new class of natural solvo-surfactants, glycerol 1-monoethers, were investigated in comparison with widespread but harmful glycol ethers. Vapour pressures and heats of vaporization were measured between 25 uC and 50 uC, and calculated thanks to two group contribution methods. Evaporation rates and Hansen parameters, evaluated from TGA measurements and group contributions respectively, were compared as well. Bionotox properties, i.e. cytotoxicity, irritating power and biodegradability, were evaluated experimentally. Glycerol 1-monoethers turned out to be less volatile than glycol derivatives, but contrary to the latter they will not be considered as VOCs. Toxicities and irritating powers are equivalent and increase with increasing alkyl chain length, i.e. with increasing amphiphilicity. Glycerol ethers are degradable at lower concentrations compared to glycol compounds, which is related to their higher interfacial activity.

For many disinfection formulations, antimicrobial activity at slightly alkaline pH values is required. To date, only the wild-type vanadium chloroperoxidase has been studied for its antibacterial activity, and only at acidic to neutral pH values. Its antiviral activity (e.g. useful for the cleaning of medical equipment) was not studied before. The observed activity for the alkalophilic P395D/L241V/T343A mutant is an important step forward in the application of this robust enzyme as a component in disinfection formulations.

Rationale:Resistant cytomegalovirus-mediated infections are increasing in solid organ recipient with few available alternative treatments. Brincidofovir is an oral broad-spectrum antiviral in development for prevention and treatment of viral infection, particularly cytomegalovirus.Patients concerns:Although brincidofovir is an analogue of cidofovir, previous studies reported no renal toxicity.Diagnoses:Here, we report 2 cases of severe tubular necrosis in solid organ recipients, 1 heart and 1 kidney transplant.Interventions:Both patients received brincidofovir for the treatment of cytomegalovirus infection with mutation of UL-97. They presented an acute kidney injury without any occurrence of other clinical event such as introduction of nephrotoxic drug, graft rejection, urinary tract obstruction or infection, and calcineurin inhibitor overdosage. In each case, renal biopsy showed extended tubular necrosis.Outcomes:The discontinuation of brincidofovir led to improve renal function without other any intervention. Reintroduction of brincidofovir in case 1, due to the absence of other medical alternative, led to a new episode of acute kidney injury. One more time, renal biopsy showed tubular necrosis and patient recovered renal function after discontinuation.Lessons:To our knowledge, this is the first report of brincidofovir-mediated renal adverse event. Clinicians may be aware of this severe complication in this specific population.