Objective: Self-Instructional Module (SIM) is the self-contained typed written instructional material about the importance and prevention of cervical cancer prepared by an investigator. Instructional material given to the study subjects after a pre-test and self-evaluate by them before the post-test. Therefore, the present work aimed to find the effectiveness of SIM regarding cancer of the cervix and its prevention among married women in India. Results: SIM administrated to 60 married women after assessing pre-test knowledge on the prevention of cancer cervix. The study showed that there was a greater increase in mean post-test knowledge score 24.92 (±2.560) compared to that of the mean pre-test knowledge score 8.65 (±3.369). The paired t-test value for overall knowledge was 30.73 with the post-test mean percentage score (83.06) was high when compared to that of the mean percentage of pre-test knowledge score (28.83).