Background and study aims: EndoClot is a novel topical hemostatic powder approved for use in non-variceal upper gastrointestinal bleeding. This study examines its impact as rescue therapy in the management of gastrointestinal bleeding for which standard endoscopic therapy failed to achieve hemostasis. Methods: This observational study covered a 24-month period. Data were collated from patients treated with EndoClot for comparison with a cohort of patients managed with standard endoscopic therapy. End points of this study included immediate hemostasis, 30-day rebleed rate, 30-day mortality rate, and adverse events. Results: Between April 1, 2012, and March 31, 2014, gastroscopic procedures were performed in 1009 patients, of whom 173 required endoscopic therapy. EndoClot was used in 21 patients, with immediate hemostasis achieved in all cases, a 30-day rebleed rate of 4.8 % (95 % confidence interval [95 %CI] – 4.34 % to 3.94 %), and a 30-day mortality rate of 19.0 % (95 %CI 2.29 % – 35.91 %). Despite higher risk bleeds in this cohort of patients, Fisher's exact test demonstrated no significant difference between their 30-day mortality rate (P = 0.51) and rebleed rate (P = 0.31) and those of the patients treated with standard endoscopic hemostatic techniques. Conclusions: This study demonstrates that EndoClot can be used both safely and effectively in the management of non-variceal upper gastrointestinal bleeding.

The electrogastrogram is abnormal in approximately 36% of functional dyspepsia patients and has a specificity of approximately 93%. Electrogastrography defines a subgroup of patients with functional dyspepsia and electrical rhythm disturbance. In irritable bowel syndrome, the electrogastrogram is usually abnormal only if concurrent dyspepsia is present.

The electrogastrogram is abnormal in approximately 36% of functional dyspepsia patients and has a specificity of approximately 93%. Electrogastrography defines a subgroup of patients with functional dyspepsia and electrical rhythm disturbance. In irritable bowel syndrome, the electrogastrogram is usually abnormal only if concurrent dyspepsia is present.

The Registry reports on endoscopic therapy for Barrett's neoplasia, representing real-life outcomes. Patients with IMC were more likely to have visible lesions requiring initial EMR than those with HGD, and may carry a higher risk of cancer progression in the medium term. The data consolidate the approach to ensuring that these patients undergo thorough endoscopic work-up, including EMR prior to RFA when necessary.

INTRODUCTIONNon-ulcer dyspepsia (NUD) is characterized by persistent or recurrent epigastric symptoms including pain and fullness, early satiety, nausea, and/or vomiting that are not explained by structural or biochemical abnormalities. 1 Recent studies have indicated that NUD might be a result of abnormalities in gastric physiology. NUD patients demonstrate a reduced sensory threshold to gastric distension compared to controls. 2±4 Motor abnormalities include a decreased antral and/or antroduodenal contractile response to the ingestion of a meal or uncoordinated and/or non-propagated duodenaljejunal motor waves. 5,6 These abnormalities of gastric motor physiology are often accompanied by delayed gastric emptying 7±10 and maldistribution of food in the stomach. 11 The maldistribution of food may also be related to impaired gastric accommodation, 2 resulting in increased food loading of the antrum following a meal. The electrogastrogram (EGG) is a non-invasive test used to measure gastric myoelectrical activity. Normal gastric myoelectrical activity consists of a slow wave and spike potentials. The EGG accurately records the slow wave, which controls the velocity and propagation of gastric contractions. Previous studies have demonstrated that the EGG is reproducible and stable over time. 12 In addition, the EGG is not affected by age or gender. 13 The EGG detects gastric dysrhythmias, either fast frequency waves (tachygastria) or slow frequency waves (bradygastria). Studies using serosal transducers and manometry have shown that tachygastrias correlate with absent antral contractions 14 and bradygastrias are associated with both strong and or absent antral SUMMARY Background: The electrogastrogram (EGG), which records gastric myoelectrical activity, is abnormal in onethird of adult patients with non-ulcer dyspepsia (NUD). Aim: To observe the effects of cisapride on EGG in adults with NUD. Methods: Twenty-seven NUD patients who had undergone a pre-and post-prandial EGG were entered into an open study. All patients completed a dyspepsia symptom questionnaire and were then treated with cisapride 10 mg t.d.s. The dyspepsia questionnaire was repeated in all those completing 4 weeks of treatment. Those with an initial abnormal EGG (< 70% of slow wave