Shigellosis is an acute inflammatory disease in the human digestive tract. One of the pathogenic bacteria that causes shigellosis is Shigella dysenteriae. Some natural ingredients believed to have good antibacterial activities are Meniran (Phyllanthus niruri L.) and Kenikir (Cosmos caudatus Kunth.). This study aimed to determine the compound groups and evaluate the antibacterial activity combination of Meniran (Phyllanthus niruri L.) and Kenikir (Cosmos caudatus Kunth.) leaf ethanolic extracts against Shigella dysenteriae. The ethanol extract of meniran leaves (M) and kenikir leaves (K) was made in five different combinations with three replications. The extraction was carried out by maceration method using a 96% ethanol. The concentration of the extract used was 50% with 3% DMSO dilution. The chemical compound groups were identified using various chemical reagents. The antibacterial activity test was carried out by the diffusion method. The antibacterial activity data of Meniran and Kenikir leaf ethanolic extracts were analyzed by the analysis of variance. The results showed that the ethanolic extracts of Meniran and Kenikir leaves contained several compound groups, such as saponins, tannins, alkaloids, flavonoids, and polyphenols. The ethanolic extract of Meniran leaves contains flavonoids, tannins and alkaloids with consentrations of 37.6 mgQE/g, 141 mgTAE/g, and 4.28 mgK/g, respectively. The ethanolic extract of Kenikir leaves contains flavonoids, tannins and alkaloids with consentrations of 33.8 mgQE/g, 76 mgTAE/g, and 4.603 mgK/g, respectively. The ethanolic extracts of Meniran and Kenikir leaves had antibacterial activity against S. dysenteriae. The most effective antibacterial composition was M 1:0 K, with an inhibition zone of 14.3 mm. The best antibacterial activity against Shygella dysenteriae is found in Meniran leaf ethanolic extract without combination with Kenikir.