The impacts generated by the products and manufacturing systems have led to the distancing of natural capital and social capital causing a metabolic fracture, which has led to a change in the sustainable awareness of the manufacturing industry. This has led to the creation and development of new paradigms of sustainability among which is the circular economy. In the context of Industrial Ecology, there are a set of work frameworks, among which are the Life Cycle Analysis (LCA), focused on eco-efficiency, and Crade to Crade (C2C), in the eco- effectiveness, which allow the evaluation, eco-innovation and eco-design of the sustainability of products, from the effects of the impacts in the first case and from the causes in the second. The objective of this work is focused on the development of a framework proposal that combines both perspectives and that a new assessment of impacts is articulated by exploiting the potentialities that result from the connectivity, intelligence and digitalization of cyber-physical systems in the context of Industry 4.0 and manufacturing in the cloud for the evolution of products towards the new concept of smart connected product (intelligent connected product). Keywords: Circular Economy, LCA, C2C, Industry 4.0.

Once the framework for the integrated evaluation of sustainability connected from the circular economy paradigm in the context of the cyber-physical systems of Industry 4.0 has been developed, this paper develops the methodological model that makes it possible to obtain an evaluation of the impacts of the three dimensions (environmental, economic and social impacts) by analyzing their effects (LCA) and their causes (C2C). The articulation of the model from these two frameworks (ACV and C2C) has determined that it has a structured bionic inspiration in two phases. The first of these, the adenomic phase, fixes the genes of the product through design, and in the second, the domestic phase, which integrates the aspects of sustainability derived from the phenotypic evolution of the product. Due to the digitalization of Industry 4.0, the product evolves towards the connected intelligent product equipped with sensors that collect information in real time, evolving sustainable development towards connected sustainability. The evaluation model is connected to an IoT platform composed of different processing layers and connected to external information sources to incorporate the necessary data to carry out a complete and integrated evaluation. This model supports the product data under ISO 10303 (STEP). Keywords: Circular Economy, LCA, C2C, Industry 4.0, STEP

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