This paper provides a systematized overview of patterns in the scenario planning literature published in the last decades. Recently, scenario planning has enjoyed a revival, apparent in the "boom" in published research on the matter. Consequently, a major issue that needs to be addressed is how to organize the literature along precise lines.A number of reviews that describe the current status of the body of literature and knowledge on scenario planning have made attempts to respond to such requirements. These studies agree that systematizing the existing literature is a necessary step in developing the field. This paper aims to contribute to this purpose. The review of the academic literature here conducted is thought to be useful for both academics and practitioners. For researchers, this systematic overview will not only be constructive in providing an analysis of the directions of published research but also in setting up a research agenda for the future. For managers and practitioners, it provides a clear outline of firmrelated articles and discusses their contribution from a managerial point of view. It also raises awareness with regard to future analytical methods, and in particular, to scenario planning and its potential contribution to the competitiveness of firms.

BackgroundThe need to manage large amounts of data is a clear demand for laboratories nowadays. The use of Laboratory Information Management Systems (LIMS) to achieve this is growing each day. A LIMS is a complex computational system used to manage laboratory data with emphasis in quality assurance. Several LIMS are available currently. However, most of them have proprietary code and are commercialized with a high cost. Moreover, due to its complexity, LIMS are usually designed to comply with the needs of one kind of laboratory, making it very difficult to reuse a LIMS. In this work we describe the Sistema Integrado de Gerência de Laboratórios (SIGLa), an open source LIMS with a new approach designed to allow it to adapt its activities and processes to various types of laboratories.ResultsSIGLa incorporates a workflow management system, making it possible to create and manage customized workflows. For each new laboratory a workflow is defined with its activities, rules and procedures. During the execution, for each workflow created, the values of attributes defined in a XPDL file (which describe the workflow) are stored in SIGLa’s database, allowing then to be managed and retrieved upon request. These characteristics increase system’s flexibility and extend its usability to include the needs of multiple types of laboratories. To construct the main functionalities of SIGLa a workflow of a proteomic laboratory was first defined. To validate the SIGLa capability of adapting to multiples laboratories, on this paper we study theprocess and the needs of a microarray laboratory and define its workflow. This workflow has been defined in a period of about two weeks, showing the efficiency and flexibility of the tool.ConclusionsUsing SIGLa it has been possible to construct a microarray LIMS in a few days illustrating the flexibility and power of the method proposed. With SIGLa’s development we hope to contribute positively to the area of management of complex data in laboratory by managing its large amounts of data, guaranteeing the consistence of the data and increasing the laboratory productivity. We also hope to make possible to laboratories with little resources to afford a high level system for complex data management.

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No final do ano de 2015, observou-se um aumento exponencial no número de casos notificados de recém nascidos com microcefalia, definida pela medida do perímetro cefálico (PC) menor que dois desvios padrões em relação a média populacional, para dado sexo e idade gestacional, segundo a Organização Mundial de Saúde (OMS). Em consonância a isso, a infecção pelo Zika vírus (ZIKV), uma arbovirose emergente no país, tornou-se uma endemia. Este trabalho tem como objetivo estudar a associação da infecção intra-útero pelo Zika vírus e a ocorrência de microcefalia no período neonatal, apresentando os dados mais recentes referente à etiologia, epidemiologia e fisiopatologia da Síndrome do Zika vírus, além de descrever os desfechos relacionados a exposição ao ZIKV na gestação e avaliar o prognóstico das crianças afetadas pela microcefalia. Foi realizada uma revisão de literatura a partir de artigos científicos, livros e boletins epidemiológicos na elaboração do presente estudo. Assim, verificou-se que os portadores de microcefalia associada ao ZIKV apresentam atraso importante no desenvolvimento neuropsicomotor associado a alterações visuais, auditivas e sensoriais, o que irá impactar na independência funcional e na inserção social dos mesmos. Ainda são escassos os conhecimentos sobre essa síndrome, tanto sobre sua evolução natural, como dos seus fatores de risco ou associados, sendo necessários mais estudos sobre a temática. Palavras–chave: Vírus Zika, Gestação, Microcefalia.