Chitosan (CS) is a linear copolymer of β-(1-4)linked 2-acetamido-2-deoxy-beta-D-glucopyranose and 2-amino-2-deoxy-3-D-glucopyranose, obtained by deacetylation of its parent polymer chitin, the second most abundant in nature after cellulose [1] . The bactericidal action of CS is well known and is due to an electrostatic interaction between NH 3 + groups of CS and phosphoryl groups of phospholipid components and lipopolysaccharides of bacterial cell membranes. This leads to an increase in the permeability formation of pores and finally disrupts the bacterial cell wall [2][3][4] . Bacterial infectious diseases ranging from cutaneous infection to deep-seated life-threatening infections such as pneumonia, endocarditis, septicaemia, osteomyelitis, and other metastatic complications [5][6][7] . Antibiotic are the usual treatment for bacterial infection [8] . Bacterial infectious disease is still responsible for considerable global mortality despite antibiotic treatment [9][10][11] . The major challenges faced by localized treatment of respiratory tract infections are the rapid absorption and clearance of antibiotics from the lungs. A critical obstacle and challenge for bacterial infectious therapy concerns the limited availability of effective biocompatible delivery system for most hydrophobic therapeutic and antimicrobial resistance. Intracellular infections and acquired resistance of infectious microbes are also key challenges [12] .The clinical treatment failure of bacterial infectious disease is associated with low bioavailability of antibiotics, side effects of antibiotics, tissue and cellular barriers, biofilm-related infection and the emergence of resistant bacteria. Polymeric nanoparticles (NPs) and microparticles have been shown to have the potential to provide controlled drug delivery to the lungs, with sustained release of drugs so as to prolong drug