Aim Denture cleansers are used not only to clean dentures but also for disinfection of dentures. Among household denture cleansers, bleach (which contains sodium hypochlorite) and vinegar (which contains acetic acid) have been found to be powerful disinfecting agents. The objectives of this in vitro study were to evaluate and compare the color stability and tensile bond strength of Trevalon and Lucitone 199 heat-cured resins after immersing in household denture cleansers like 1% household bleach and 50% vinegar. Methodology A total of 48 Trevalon and Lucitone 199 heat- cure resin samples respectively were fabricated. The samples were divided into three groups of 16 samples each. They were immersed in 1% bleach, 50% vinegar and water (control) respectively. The samples were alternatively immersed in cleanser and water for 8 hours for 20 days simulating 30 days of use. At the end of 20 days, color stability and tensile strength were assessed with the help of spectro-guide and Instron universal testing machine respectively. Results Sodium hypochlorite and vinegar affected the color stability of Lucitone 199 heat-cure acrylic resin. The color of Trevalon heat-cure resin remained unaltered after immersion in both the cleansers. The change in tensile strength of both the resins was not significant after immersion in both the cleansers as compared with water which was used as control group. Conclusion This study concludes that for disinfection and cleansing of denture, sodium hypochlorite can be considered as long as the acrylic used is cross linked. How to cite this article Patankar AS, Meshramkar R, Nadiger R, Bagchi P. Effect of Household Denture Cleansers on Color Stability and Tensile Bond Strength of Two Different Heat Polymerized Acrylic Resins. Int J Prosthodont Restor Dent 2015;5(4):95-100.