Biomarkers are highly specific and sensitive indicators of disease activity. Resistin is a recently discovered adipocytokine, having a potent biomarker quality. Initially resistin was thought to be produced by adipocytes alone; however, emerging evidence suggests that it is also produced in abundance by various cells of the immunoinflammatory system, indicating its role in various chronic inflammatory diseases. Data suggests that resistin plays a role in obesity, insulin resistance, cardiovascular diseases, and periodontitis. Resistin derived its name from the original observation that it induced insulin resistance (resist-in: resist insulin) in mice and is downregulated in mature murine adipocytes cultured in the presence of insulin sensitizing drugs like thiazolidinediones. It is well recognized that obesity, is associated with insulin resistance and diabetes. A three-way relationship has been established between diabetes, obesity and periodontitis. Recent evidence also suggests an association between obesity and increased risk for periodontitis. Our previous research showed incremental elevation of resistin with periodontal disease activity and a reduced level of resistin, after periodontal therapy. Thus resistin would be one of the molecular links connecting obesity, periodontitis, and diabetes and may serve as a marker that links periodontal disease with other systemic diseases. A Medline/PubMed search was carried out for keywords “Diabetes Mellitus,” “Periodontitis,” and “Resistin,” and all relevant research papers from 1990 in English were shortlisted and finalized based on their importance. This review provides an insight into the biological action of resistin and its possible role in periodontitis influenced diabetes mellitus and diabetes induced periodontitis.

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A case of severe Class II skeletal malocclusion with anterior open bite having vertical growth pattern and matching soft tissue profile is presented. Considering age of the patient and the severity of the malocclusion, it was decided to combine orthodontic treatment with surgery. A 0.022 Roth Pre-adjusted Edgewise Appliance was chosen for the orthodontic correction and Le-Fort 1 differential vertical impaction of maxilla with mandibular autorotation and augmentation genioplasty was considered as the treatment plan. The main aim was to reduce the gummy smile and correct the class II profile.

Aim Denture cleansers are used not only to clean dentures but also for disinfection of dentures. Among household denture cleansers, bleach (which contains sodium hypochlorite) and vinegar (which contains acetic acid) have been found to be powerful disinfecting agents. The objectives of this in vitro study were to evaluate and compare the color stability and tensile bond strength of Trevalon and Lucitone 199 heat-cured resins after immersing in household denture cleansers like 1% household bleach and 50% vinegar. Methodology A total of 48 Trevalon and Lucitone 199 heat- cure resin samples respectively were fabricated. The samples were divided into three groups of 16 samples each. They were immersed in 1% bleach, 50% vinegar and water (control) respectively. The samples were alternatively immersed in cleanser and water for 8 hours for 20 days simulating 30 days of use. At the end of 20 days, color stability and tensile strength were assessed with the help of spectro-guide and Instron universal testing machine respectively. Results Sodium hypochlorite and vinegar affected the color stability of Lucitone 199 heat-cure acrylic resin. The color of Trevalon heat-cure resin remained unaltered after immersion in both the cleansers. The change in tensile strength of both the resins was not significant after immersion in both the cleansers as compared with water which was used as control group. Conclusion This study concludes that for disinfection and cleansing of denture, sodium hypochlorite can be considered as long as the acrylic used is cross linked. How to cite this article Patankar AS, Meshramkar R, Nadiger R, Bagchi P. Effect of Household Denture Cleansers on Color Stability and Tensile Bond Strength of Two Different Heat Polymerized Acrylic Resins. Int J Prosthodont Restor Dent 2015;5(4):95-100.

Background: Abutment surfaces are being designed to promote gingival soft tissue attachment and integration. This confirms implant survival for long term by forming a seal around the prosthetics. Objectives: This study was done to compare the biocompatibility of three implant abutments: titanium uncoated, Ti-nitride coated, and modified polyetheretherketone (PEEK) with human gingival keratinocytes. Materials and Methods: The titanium-uncoated, titanium-nitride-coated, and modified PEEK discs (13 mm × 3 mm) were fabricated and compared with uncoated polyester cell culture discs, which were used as controls. These three implant abutments were evaluated for biocompatibility with respect to human gingival keratinocytes for viability, morphology, proliferation, and migration by scanning electron microscopy imaging and scratch wound healing assays. Measurements of roughness show changes between the investigated surfaces. Results: Keratinocytes cultured on all examined surfaces indicated adhesion and attachment. An assay of cell viability showed no substantial variances among the groups. The modified PEEK surface showed greater cell proliferation and migration among the three abutment materials. Conclusion: All three abutment material surface types showed similar epithelial biological responses. However, modified PEEK material showed the highest biocompatibility.