To describe clinical, radiographic, and morphologic findings in patients with IgG4-positive cells present on orbital biopsy specimens.

No abstract

Kikuchi-Fujimoto disease (KFD) is a rare benign disorder predominantly affecting young adults and has a site predilection for cervical lymph nodes. The objective of this study is to analyze the clinicopathological features of KFD. A retrospective study of 24 cases of KFD presenting at a tertiary care hospital in southern India over a 4 year period is presented here. Clinical findings, histopathological findings and follow up data were reviewed. Of the 24 cases encountered, 17 were females and 7 were males. Painless cervical lymphadenopathy was the most common presenting feature. All cases showed typical morphology of KFD with necrosis, karyorrhectic debris and presence of the typical cell types namely crescentic histiocytes and plasmacytoid monocytes. Of the 19 cases with follow up, all resolved within 1 month. The pathologist should be aware of the typical presentation and morphology of KFD in order to distinguish it from the more common causes of cervical lymphadenopathy like tuberculosis (especially in countries like India) as well lymphomas.

Hydatid disease may present as a slow-growing cyst in the sublingual region. Aspiration cytology should preferably be avoided until radiological imaging studies are complete. A high index of suspicion is necessary to diagnose hydatid disease in an unusual location.

Extraskeletal myxoid chondrosarcoma (EMC) is a rare soft tissue sarcoma with limited literature available on its cytological features. We report here one such case where a diagnosis of EMC was made based on fine needle aspiration cytology (FNAC). A 51 year-old male presented to our FNAC clinic with a slowly growing mass in the left thigh, which was subjected to fine needle aspiration biopsy. Radiological images showed no involvement of the underlying bone. Magnetic resonance imaging was suggestive of a malignant neoplasm. The FNA smears showed cell fragments and cords of monotonous cells embedded in abundant myxoid stroma. A diagnosis of a myxoid sarcoma favoring an EMC was made in this patient. Subsequent excision of the mass for histopathological examination confirmed this diagnosis. EMC has distinctive cytological features that are helpful in confidently making a diagnosis in the appropriate clinical setting.