Some novel quinazoline derivatives are prepared via one-pot reaction of 2-amino-5-chlorobenzophenone, aromatic aldehydes and ammonium acetate using two different types of catalytic systems including nano-magnetic piperidinium benzene-1,3-disulfonate salt (PBDS-SCMNPs), and triethanolam-monium-2,2,2-trichloroacetate (TEATCA). The highlighting points of using PBDS-SCMNPs are easy purification, reusability of the catalyst, good yields of products with short time reactions compared with TATCA.