T4b buccal cancers have significant soft-tissue involvement in the masticator space. En bloc removal of all soft-tissues in masticator space is advocated to remove tumor contained within space. The compartment surgery provides an opportunity to achieve negative margins for cancers actually contained within masticator space.It is inappropriate to club all patients with masticator space involvement in one group.

The results suggest a prevalence of KRAS mutation at 42.8% in Indian population indicating that this testing is very crucial for targeted therapy management in metastatic CRC in India. Further analysis on mutation status of other homologues such as NRAS and downstream partner, v-raf murine sarcoma viral oncogene homolog B1, would add value to understanding the role of anti-epidermal growth factor receptor therapy in CRC management.

No abstract

Granulocytic sarcoma in a patient with acute promyelocytic leukemia (APML) has been described often in the relapse setting, however primary presentation of APML as granulocytic sarcoma is rare. We present a case of a 29 year old male who was evaluated for thrombocytopenia with haematochezia and a diagnosis of acute promyelocytic leukemia was established after the colonic biopsy was reported as a granulocytic sarcoma.

Histiocytic sarcoma (HS) is a rare, non-Langerhan's, malignant histiocytic neoplasm that occurs in lymph nodes and extranodal sites mainly the skin and intestine. Amidst the cases reported so far; majority of the cases previously diagnosed as HS have been Primary T cell lymphomas (PTCL). Cases primarily involving the extranodal sites are rare, with a confusing clinical picture and thus, are often misdiagnosed. Here we report a rare case of extranodal HS in a 54-year-old man, a previously treated case of gastrointestinal stromal tumor (GIST) of the stomach, who now presented with abdominal pain. On imaging, a growth was detected in the small bowel without accompanying lymphadenopathy.