The prevalence of hyperuricemia has been increasing in both developed and developing countries. The purpose of present study was to know the prevalence of hyperuricemia in the population of Chitwan district as well as to compare the prevalence of hyperuricemia between Mongolian and non-Mongolian races of Chitwan district, who had attended the College of Medical Sciences and Teaching Hospital, Bharatpur, Nepal during the period of January 1999 to December 2003. In this study 3794 subjects were investigated for serum uric acid level (SUA). Hyperuricemia is defined as SUA more than 7mg/dl for males and menopausal women and 6mg/dl for pre-menopausal females. SUA was estimated by Caraway method in digital colorimeter. Overall prevalence was 21.42%; the condition was more common in men than women (26.78% vs. 16.82%; p<0.001). The prevalence was higher in Mongolian than non Mongolian both in males and females (24.50 % Vs 21.06%; p>0.05). Key words: Hyperuricemia; SUA; digital colorimeter DOI: 10.3126/jcmsn.v6i2.3612   Journal of college of Medical Sciences-Nepal, 2010, Vol.6, No-2, 18-23

Objective: To see the effect of consumption of locally distilled alcohol (country liquor) continuously for few months on hepatic vitamin A and C status in albino rats. Materials and methods: The study was conducted in 36 male wistar strain albino rats for 3-4 months old consisting six groups of six animals each. Results: The first observation was weight gain among the series of alcoholic animals when compared to the control and alcoholic fed animals supplemented with vitamin A and C, p-value by T-test between the mean values of the initial weight and final weight was < 0.01 (0.006), significant. Conclusion: It was found that the major effect on hepatic vitamin A and C contents were observed more distinctly in mitochondrial fractions when compared with the rest fractions. Supplementation of vitamins helped to protect loss of the vitamins which delayed the aging process at age 9-10 months in our study. Key words: Albino rats; alcoholic; hepatic; vitamin A DOI: 10.3126/jcmsn.v6i1.3599 Journal of College of Medical Sciences-Nepal, 2010, Vol. 6, No. 1, 29-34