Congenital heart disease is the most frequent malformation. In the most recent data has a prevalence of thirteen cases per 1,000 children and six cases per 1,000 adults. Great strides in pediatric cardiovascular surgery have increased the number of survivors, especially in adulthood. Nowadays more adults are living with congenital heart disease than children, particularly in developed countries, and more than two thirds fall into the categories of moderate and high complexity defects. This growing population called: Grown up congenital heart, requires super-specialized healthcare, the profile of the new cardiovascular patient differs from the traditional adult with heart disease, the first paradigm that should be broken is to understand that cardiovascular surgery is restorative (it substantially improves the hemodynamic condition), but is not 100% curative. Surgical and survival successes have turned the pediatric patient with congenital heart disease into an adult postoperative patient with residua, sequela and complications. The adult's postoperative heart is not a natural heart, it is a transformed, "neo-formed", heart. They will have relapses and hospitalizations due decompensation to congenital heart disease. A new specialist profile is necessary. Training in adult congenital heart disease is valid beginning from both a pediatric and an adult cardiology environment. The special needs of this population are very costly for health systems. Recognize what are the main causes of decompensation is mandatory and finally adequate care decreases prolonged hospital stays and health system cost.

The novel coronavirus causes severe acute respiratory syndrome 2, and can infect any population. With the currently available information on the behavior of the pandemic, we conclude that the virus has come to stay. It is clear that the most aggressive behavior and worst outcome of the infection occurs in already established risk groups, such as those with cardiovascular disease. Those with congenital heart disease make up a special risk group. Due to this group's high heterogeneity and the paucity of published cases related to coronavirus infection, its ultimate behavior cannot yet be known. Based on the anatomical and hemodynamic abnormalities with systemic repercussions which accompany congenital heart disease, this review was carried out with the aim of describing and analyzing this population's risk factors and potentially increased vulnerability to coronavirus infection. Systemic hematological abnormalities, along with the prothrombotic state, proinflammatory state, and altered immune response in cyanotic congenital heart disease are highlighted; along with the arrhythmias, pulmonary hypertension, underlying heart failure and target organ damage, among others, present in unrepaired congenital heart disease. This review searched for articles in PubMed, Science Direct, SciELO, MD Consult and Google Scholar using the MeSH terms "coronavirus disease 2019", "COVID-19", "SARS-CoV-2 pandemic", "coronavirus and cardiovascular system", "congenital heart diseases", "hematologic disorders in congenital heart disease", and "pro-inflammatory mediators". Finally, a brief description of the collateral effects of the pandemic on the care of this population is provided.

Myxomas are low-prevalence heart tumors in the pediatric population. They are located in the left atrium in 75-86% of cases, and 30-50% are accompanied by general symptoms such as fever, weight loss, myalgias, arthralgias and elevated inflammatory markers caused by IL-6 release. They are rapidly growing heart tumors, and their most important complications are valvular and ventricular inflow tract obstruction, which may cause sudden death. Three to ten percent of cases are associated with Carney complex (CNC), type 1, caused by a mutation of the PRKAR1A gene on chromosome 17. We present the case of a 10-year-old girl with general symptoms, a murmur, syncope, hemolytic anemia and multiple nevi, in whom a giant obstructive myxoma was found in the left atrium. Carney complex, type 1, was confirmed. She underwent successful surgical resection with no complications.

Adults with congenital heart disease are a growing population in Colombia and worldwide. Currently, Colombia has a population of more than 51 million inhabitants, with 38.2 million adults, 115,000 of whom live with congenital heart disease of varying complexity. The demographic profile shows that this population with congenital heart disease is mostly young, with ages ranging from 20 to 44 years. Keeping them in optimal health is a challenge, and care involves centralization in special adult congenital heart disease units. This manuscript is a narrative review of the current situation of adults with congenital heart disease living in Colombia. Colombia's current population pyramid is analyzed, and the demographic profile of the adult population with congenital heart disease is described. Finally, the strategies used for developing an adult congenital heart disease unit in Colombia are described, based on the comprehensive model of specialized care for a growing population.

Systemic polyarteritis nodosa is a vasculitis characterized by inflammation and fibrinoid necrosis of medium and small arteries, with a global incidence of 0.7/100,000 and a prevalence of 6.3/100,000. Its cause is as yet unknown, and it affects both children and adults. The clinical presentation tends to be insidious and vague in its initial stages. Cardiac involvement is one of the signs of severity, with coronary artery impairment and aneurysmal lesions of varying degrees. The consequent heart failure and acute myocardial infarction are complications which increase mortality. Without treatment, five-year survival is 13%. Medical treatment is aimed at halting the inflammatory process and treating the consequences of the dysfunction of various organs and systems. We present a case of an eight-year-old boy with polyarteritis nodosa who developed giant aneurysms of the coronary arteries with severe cardiac dysfunction and multisystem impairment. The proper diagnosis and prompt treatment achieved clinical recovery and early survival.