No abstract

Modernization of society have caused various momentous changes in dietary habits of people in this era of modern world. The modern dietary patterns are typically composed of Fatty acids mainly saturated fatty acids along with refined carbohydrates. This present-day diet together with a lifestyle with reduced physical activity is a major determinant of various metabolic disorders like obesity and diabetes. All these factors are also causing a gradual increase in the prevalence of cognitive disorders mainly depressive disorders and mood disorders. Neuroinflammation is the link between the metabolic disorders and cognitive disorders and this correlation is evident by significant clinical and epidemiological data. Fatty acids are of major interest as they have twofold functions. They are major contributors of modern diet causing obesity, diabetes and other metabolic disorders and on the other hand they serve as signaling molecules in the inflammatory responses. The difference lies in the choice of the fatty acids that are included as a part of daily diet. Saturated fatty acids are the ones should be avoided as they are the components of high caloric obesogenic diets whereas, polyunsaturated including Omega-6 and Omega-3 fatty acids must be consume through daily foods to prevent from Neuroinflammation considered to be the major cause of neuropsychiatric disorders.

BACKGROUND: Ideal blood inventory management involves guaranteeing maximal availability of blood while minimizing wastage. Benchmark for the guidance of O (Rh) D-negative red blood cells (ONEG RBCs) is not widely available. In this study, we aimed to identify the areas of improvement in blood center inventory of ONEG RBCs through a clinical audit. MATERIALS AND METHODS: During April 2017 to March 2018, patients who received ONEG RBCs units were studied for their demographics, primary reason for admission, location, and clinical condition. Data were collected from computerized blood center information system, online integrated laboratory data (Integrated Laboratory Management System), and patients’ medical record charts. Children at ≤18 years were included in the pediatric population as per our institutional criterion while a female between 15 and 49 years was considered as having childbearing potential according to previously published data. RESULTS: Overall, 807 units (2.8%) of ONEG RBCs were transfused during 577 transfusion events with a median (inter quartile range) of 2 (1–3) units per patient in each transfusion event. Recipients of ONEG RBCs were 221 unique patients including 91 females (41%) and 130 males (59%) and only 44 (20%) females had child-bearing potential. Overall, 72 of 807 red cell units (8.9%) were transfused to young females of O/non-O negative/unknown group and were classified as “obligatory.” Neonates, pediatric patients, chronically transfused, and bone marrow transplant recipients received 337 of 807 (42%) units and were marked as “acceptable.” Transfusion of 398/807 units (49%) to females of nonchildbearing potential and adult males could have been saved for those with a mandatory transfusion requirement of ONEG RBCs. CONCLUSIONS: This clinical audit showed that 409 of 807 of ONEG RBCs (51%) were transfused according to the guidelines while 398 of 807 of these (49%) could have been saved for other mandatory requirements. Appropriate policies, planning, education of physicians, and regular clinical audits are needed to bring the desired change in transfusion practices.

Modernization of society have caused various momentous changes in dietary habits of people in this era of modern world. The modern dietary patterns are typically composed of Fatty acids mainly saturated fatty acids along with refined carbohydrates. This present-day diet together with a lifestyle with reduced physical activity is a major determinant of various metabolic disorders like obesity and diabetes. All these factors are also causing a gradual increase in the prevalence of cognitive disorders mainly depressive disorders and mood disorders. Neuroinflammation is the link between the metabolic disorders and cognitive disorders and this correlation is evident by significant clinical and epidemiological data. Fatty acids are of major interest as they have twofold functions. They are major contributors of modern diet causing obesity, diabetes and other metabolic disorders and on the other hand they serve as signaling molecules in the inflammatory responses. The difference lies in the choice of the fatty acids that are included as a part of daily diet. Saturated fatty acids are the ones should be avoided as they are the components of high caloric obesogenic diets whereas, polyunsaturated including Omega-6 and Omega-3 fatty acids must be consume through daily foods to prevent from Neuroinflammation considered to be the major cause of neuropsychiatric disorders.

Human Resource Management practices are shaped by the work environment and culture of a specific country. "Localized" HR practices also determine, to a large extent, organizational effectiveness. Nevertheless, with present milieu of globalization and internationalization of businesses the pressure to adopt best practices and follow some form of international standards has become the norm. This is especially in the interest of companies who are either on the path to "globalization" or intend to go that way.Both China and India have strong indigenous cultures and work environment that has led to creation of unique Human Resource Management systems and practices in the organizational reality of each country.