Introduction: Pancreatic neuroendocrine tumors are considered rare. They are classified into functioning and non-functioning. Objective: To define and classify pancreatic neuroendocrine tumors according to their histopathological and immunohistochemical evaluation, associated with diagnostic criteria. Method: This is a narrative review of publications found in PubMed, SciELO and Google Scholar. Results: These tumors can be well or poorly differentiated and have distinct microscopic characteristics. Well-differentiated cells are small in shape, have uniform round or oval nuclei, finely granular cytoplasm indicating strong secretory capacity, and maintain the organoid structure. Presence of tumor necrosis, increased mitotic activity and high Ki-67 index indicate a high probability of neuroendocrine neoplasia. Chromogranin A and synaptophysin favor the diagnosis of well-differentiated. The positive staining of BCL 10 together with the absence of expression of chromogranin A and synaptophysin show poor tumor differentiation. The presence of positive staining for hormone expressions does not define the tumor as functioning. Conclusion: There was an increase in the diagnosis of pancreatic neuroendocrine tumors with the use of imaging techniques and awareness of the disease. Histopathological analysis with immunohistochemistry, especially when there are consuming symptoms, can indicate the type of carcinoma and lead to the most appropriate treatment.

RESUMO - A obesidade é doença crônica que pode acarretar outros graves problemas de saúde. Em casos mais severos, alternativa terapêutica é a realização de operação bariátrica. O objetivo deste trabalho foi apresentar revisão narrativa aspectos anatômicos da trombose da veia mesentérica superior após sleeve gástrico. Foi realizada análise de literatura sobre o tema no período de 2011 a 2021, utilizando-se das bases de dados Periódicos da CAPES e PubMed, empregando os seguintes descritores em inglês e português: sleeve, veia mesentérica superior e trombose. Dentre os resultados, foram selecionados 7 artigos que atendiam aos propósitos da pesquisa. Como conclusão, o sleeve é procedimento eficiente, contudo é preciso considerar a possibilidade de ocorrência da trombose da veia mesentérica superior, sendo de importância analisar previamente os fatores de risco, bem como cogitar a indicação do uso de anticoagulantes no período pré, trans e pós-operatório.

BACKGROUNDSystemic sclerosis (SSc) is an autoimmune connective tissue disease with heterogeneous clinical profile. Autoantibodies have been useful tools as disease markers and predictors of clinical manifestations and prognosis. Little is known about the role of anti-Ro/SSA antibody in this disease. Therefore, the aim of this study was to establish the prevalence of anti-Ro/SSA antibody in SSc in a local sample and its influence on the clinical-epidemiological patient's profile. METHODSThis is a retrospective study carried out through chart review. To be included patients should fulfill at least nine points of the 2013 Classification Criteria of the American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) classification criteria for SSc; to have disease beginning after 18 years of age and anti-Ro/SSA autoantibody results. RESULTSAbout 142 patients were included. The female:male ratio was 11:1, and the patients were mainly Caucasians (65.67%) with a median age of 55 years and disease duration of 11 years. SSc predominated in its limited form, with a modified Rodnan score had a median of 8. The most common findings were: presence of Raynaud's phenomenon in 97.18%; joint complaints in 53.15%, gastric complaints in 66.67%; 69.50% had esophageal dysmotility and 63.57% had interstitial lung disease. As for the laboratory test, 93.57% of the patients had positive ANA, most of them (41.86%) with a fine speckled nuclear pattern, and 37.35% had the anticentromere autoantibody. Anti-Ro/SSA was present in 24.11% of the sample. Comparing the groups according to the presence of anti-Ro/SSA, those with this autoantibody had higher prevalence of myositis (p = 0.005), xerophthalmia (p = 0.002) and secondary Sjögren's syndrome (p < 0.0001) and less skin involvement (p = 0.002). As for autoantibodies, anti-La/SSB (p < 0.0001) and anti-U1-RNP (p < 0.0001) were associated with the presence of anti-Ro/SSA; anticentromere (p = 0.02) was associated with its absence. CONCLUSIONA total of 24.11% of SSc patients had positive anti-Ro/SSA. This marker was related to a higher prevalence of myositis, xerophthalmia, secondary Sjögren's syndrome and a lower rate of skin thickening. Anti-Ro/SSA present was indicative of the presence of anti-La/SSB and anti-U1-RNP, but absence of anticentromere.

OBJECTIVES: To verify the accuracy of the Gail Model (GM) in risk assessment in patients with suspected breast cancer and to determine the need to adapt the GM or develop a new model for accurate risk assessment of these patients. METHODS: This is a descriptive, cross-sectional and retrospective study, based on the analysis of data provided by the medical records of 200 patients treated between 2017 and 2021, from the Mastology Outpatient Clinic of the Hospital Universitário Evangélico Mackenzie (HUEM). RESULTS: 155 women were diagnosed with breast cancer and 45 were not. The mean age was 54.23 years and the mean age at menarche was 13 years. Also, only 13 medical records contained information on age at birth of the 1st child or absence of children, and the mean age obtained was 26.77 years. Ethnic prevalence was white and most patients had no first-degree relatives with breast cancer. Regarding previous breast biopsies, most had already performed at least one, but few received a result of atypical hyperplasia. Furthermore, most of the study patients diagnosed with breast cancer had no positive family history of the disease. CONCLUSION: The study shows that the GM isn't reliable in assuming the risk of the studied population to develop breast CA, since, when comparing the GM data between groups that had and didn't have the disease, there was no significant difference.