Introduction and Aim: Diabetes is a disease rising all over the world affecting larger number of populations. In India largest number of diabetic patients are reported. Lack of physical activity, dietary pattern change, and sedentary life style are the major causes for concern. Aneffective lifestyle intervention including changes in dietary pattern, regular exercises would enhance in preventing or postponing the onset of diabetes. The aim of the study is to analyse  the effectiveness of Swiss ball exercise and resistance training in type 2 diabetes mellitus patients.   Materials and Methods:The study design is comparative type. The study was conducted in Faculty of Physiotherapy, Dr. MGR Educational and Research Institute, Chennai. The study sample of 30 subjects both male and female were selected based on the inclusion and exclusion criteria. The subjects were sorted into two groups.Inclusion criteria were patients with clear history of Type 2 diabetes, clinically diagnosed, an inactive lifestyle, age between 30-60 years. Exclusion criteria were uncontrolled hypertension, coronary artery disease, advanced retinopathy, neuropathy, severe orthopedic conditions. 30 subjects between the age group of 30-60 years were divided into two groups, group A and group B. Individuals in the group A (n=15) received the Swiss ball exercise and group B (n=15) received resistance training exercise for 5 session/ week for 12 weeks for 30 minutes.   Results: On comparing pre-test and post-test within group A andgroup B on fasting, post prandial blood sugar level and diabetes distress screening scale show highly significant difference in mean values at P ? 0.001.   Conclusion:The study concluded that both the groupshad substantial effect. On comparing Swiss ball exercise and resistance training, both the exercise programs were found to be equally effective.