COVID-19 pandemic has caused a sudden significant increase in hospitalizations for pneumonia with multiorgan disease. Objective: To analyze the literature on SARS-CoV-2 and its impact today, in high-impact journals. Methodology: The search was carried out in Pubmed, Google Scholar, using the terms of "COVID-19", "SARS-CoV-2", "immune response", "transmission routes", "oral manifestations", "treatment", "diagnosis" in conjunction with logical boolean operators OR, AND. Results:The innate and adaptive immune response are the key to the clinical progress of the infection, transmission is through droplets that are suspended in the air, which goes from the moment a person speaks, coughs or sneezes. Clinical diagnostic test for the detection most widely accepted is the PCR test. Loss of taste is an oral manifestation that is frequently seen in people who are infected with SARS-CoV-2. Conclusion:The immune response is an important issue to address due to the relationship that SARS-CoV-2 has with the immune system, therefore, it is of utmost importance that there is an effective treatment against SARS-CoV-2.