modulates the angiogenic response to exercise training in skeletal muscles of aged men. Am J Physiol Heart Circ Physiol 307: H1111-H1119, 2014. First published August 15, 2014; doi:10.1152/ajpheart.00168.2014In animal studies, the polyphenol resveratrol has been shown to influence several pathways of importance for angiogenesis in skeletal muscle. The aim of the present study was to examine the angiogenic effect of resveratrol supplementation with parallel exercise training in aged men. Forty-three healthy physically inactive aged men (65 Ϯ 1 yr) were divided into 1) a training group that conducted 8 wk of intense exercise training where half of the subjects received a daily intake of either 250 mg trans-resveratrol (n ϭ 14) and the other half received placebo (n ϭ 13) and 2) a nontraining group that received either 250 mg trans-resveratrol (n ϭ 9) or placebo (n ϭ 7). The group that trained with placebo showed a ϳ20% increase in the capillary-to-fiber ratio, an increase in muscle protein expression of VEGF, VEGF receptor-2, and tissue inhibitor of matrix metalloproteinase (TIMP-1) but unaltered thrombospodin-1 levels. Muscle interstitial VEGF and thrombospodin-1 protein levels were unchanged after the training period. The group that trained with resveratrol supplementation did not show an increase in the capillary-to-fiber ratio or an increase in muscle VEGF protein. Muscle TIMP-1 protein levels were lower in the training and resveratrol group than in the training and placebo group. Both training groups showed an increase in forkhead box O1 protein. In nontraining groups, TIMP-1 protein was lower in the resveratrol-treated group than the placebo-treated group after 8 wk. In conclusion, these data show that exercise training has a strong angiogenic effect, whereas resveratrol supplementation may limit basal and training-induced angiogenesis.aging; antioxidant; physical activity; capillary; vascular endothelial growth factor SUFFICIENT O2 SUPPLY to the working skeletal muscle is vital to exercise performance, and the capillary network readily adapts according to demand in young healthy subjects (51). With advancing age, as with inactivity, the capillary supply to skeletal muscle decreases (7) and physical performance is reduced (66), eventually affecting activities of daily living and life quality (44,45). Acute physical activity increases the expression of various angiogenic factors in the skeletal muscle of both young and aged subjects (16,57,58), and, over weeks, regular physical activity leads to an increase in skeletal muscle capillarization (1,5,8).

In this study we found an association between maternal glucose concentrations during labour and postnatal glucose adaptation and need for IV glucose treatment in the infants. Online monitoring of glucose levels during delivery might help us to achieve maternal normoglycaemia and further reduce the risk of postnatal hypoglycaemia in the offspring.

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Objective To compare intrapartum related infant mortality in term (> 34 weeks) breech presentations in Design Register based nationwide study.Setting Sweden from 1991 to 1992.Participants 6542 singleton fetuses born in the breech presentation.Main outcome measures Intrapartum and early neonatal deaths, stillbirths and congenital malformations, low Apgar score < 7 at 5 min, mode of delivery.Results After exclusion of antepartum stillbirths and congenital malformation, the intrapartum and early neonatal mortality rate was 212248 (0.09%) in the group delivered vaginally and 2/4029 (0.05%) in the group delivered by caesarean section. The relative risk was 1-81 (95% CI 0.26-12.84). Thus the difference was not statistically significant. This result was further supported after reviewing individual cases. ConclusionsThe intrapartum related mortality in the group delivered vaginally was low and the result could not verify an increased mortality in term breech presentations delivered vaginally compared with those delivered by caesarean section.relation to vaginal delivery or delivery by caesarean section.

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