The liver is an important organ that aids in the anabolism and elimination of xenobiotics from the body. Liver malfunction is a serious public health problem which affects not only doctors and nurses, but also the pharmaceutical industry and a governing authority of drugs. Excessive alcohol use, toxic chemicals (particular antibiotics, chemotherapeutic drugs, carbon tetrachloride (CCL4), thioacetamide (TAA), and microorganisms all induce liver cell harm. In this scenario, the current synthetic medications to treat liver problems promote more liver damage. As a result, herbal drugs have grown in popularity and are widely used. For a long time, plants have been utilized to treat hepatic illness. There are a variety of herbal preparations on the market. The goal of this review is to compile information on promising phytochemicals from medicinal plants that have been investigated in hepatotoxicity models utilising cutting-edge scientific methods.

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World is facing a new pandemic called covid-19SARS-CoV-2) since a year ago. Unfortunately there is no treatment for Covid 19 nowadays as well as no potential therapies has been developed to overcome from coronavirus pandemic. Some potential drug molecules with combination have ability to respond for covid19 virus. From the research it was found that the reduction of viral load can be treated with hydroxychloroquine and azithromycin combination. We evaluate the mode of interactions of hydroxychloroquine and azithromycin with the dynamic site of SARS-CoV-2 coronavirus main protease. Molecular Structure-based computational approach viz. molecular docking simulations were performed to scale up their affinity and binding fitness of the docked complex of novel SARS-CoV-2 coronavirus protease and hydroxychloroquine and azithromycin. The natural inhibitor N3 of novel SARS-CoV-2 coronavirus protease were exhibited highest affinity in terms of MolDock score (-167.203Kcal/mol), and hydroxychloroquine was found with lowest target affinity (-55.917 Kcal/mol).The amino acid residue cysteine 145 and histidine 41 is bound covalently and formed hydrogen bond interaction with SARS-CoV-2 inhibitor known as inhibitor N3 as such, hydroxychloroquine and azithromycin also formed hydrogen bond interaction. The binding patterns of the inhibitor N3 of SARS-CoV-2 coronavirus main protease could be used as a guideline for medicinal chemist to explore their SARS-CoV-2 inhibitory potential.