Aim: To assess the risk factors of visual field defects in primary open-angle glaucoma Study design: A retrospective cross-sectional study Place and Duration: Institute of Ophthalmology LUMHS, Jamshoro from May 2020 to April 2021 Methodology: This study comprised a total of 100 participants with glaucoma. Males outnumbered females in the gender distribution. Instead of using a formal definition defined by the investigators, a clinical diagnosis of POAG was used in this investigation. In the presence of gonioscopically open anterior chamber angles in both eyes, POAG was pragmatically defined as glaucomatous visual field defects (GVFD). Results: Primary open-angle glaucoma affected 80 percent of men and 20 percent of women. The prevalence of open-angle glaucoma was 44 percent in the 55-65-year-old group, and 30 percent in the 45-54-year-old group. In 44 percent of instances, the eyesight loss lasted two years, whereas 31 percent had a one-year history. Hypertension was observed in 23.5 percent of patients with primary open-angle glaucoma, followed by myopia and diabetes. Conclusion: It was observed that hypertension was the leading risk factor of Primary Open angle glaucoma, followed by myopia, family history, diabetes, and smoking. Keywords: Glaucoma, risk factors, hypertension, diabetes