Transient molecules in the gastrointestinal (GI) tract, such as nitric oxide and hydrogen sulfide, are key signals and mediators of inflammatory bowel disease (IBD). Because these molecules are extremely short-lived in the body, they are difficult to detect. To track these reactive molecules in the GI tract, we have developed a miniaturized device that integrates genetically-engineered probiotic biosensors with a custom-designed photodetector and readout chip. Leveraging the molecular specificity of living sensors, we genetically encoded bacteria to respond to IBD-associated molecules by luminescing. Low-power electronic readout circuits (nanowatt power) integrated into the device convert the light from just 1 μL of bacterial culture into a wireless signal. We demonstrate biosensor monitoring in the GI tract of small and large animal models and integration of all components into a sub-1.4 cm3 ingestible form factor capable of supporting wireless communication. The wireless detection of short-lived, disease-associated molecules could support earlier diagnosis of disease than is currently possible, more accurate tracking of disease progression, and more timely communication between patient and their care team supporting remote personalized care.

We present the first fully-integrated universal Maximum Likelihood decoder in 40 nm CMOS using the Guessing Random Additive Noise Decoding (GRAND) algorithm for lowpower applications. The 0.83 mm 2 multi-code multi-rate universal decoder can efficiently decode any code of length up to 128 bits with 1 µs latency at 68 MHz. Dynamic clock gating leveraging noise statistics reduces the average power dissipation to 3.75 mW at 1.1 V or 30.6 pJ/decoded bit with a throughput of 122.6 Mb/s. Universal decoding reduces hardware footprint, and the design allows seamless swapping between codebooks with no downtime, enabling use by multiple applications without switch-over.

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