The purpose of this paper is to determine the active form of matrix metalloproteinases (MMP-2 and MMP-9) in corneal ulcer and ocular surface disorder patients. A total of 35 patients of corneal ulcer, 20 patients of ocular surface disorders and 10 control subjects were included in this study and estimation of active form of MMP-2 and MMP-9 was done by gelatin zymography. Tear samples were collected by capillary tube method. Both pro-and active forms of MMP-9 were detected in 24 out of 35 patients with corneal ulcer and 15 out of 20 patients with ocular surface disorders. None of the patients were showing MMP-2 activity. Neither MMP-2 nor MMP-9 was detected in the control group. Active forms of MMP-9 are present in tears of severe ulcerative and ocular surface disorder patients. Thus, proteinase inhibitors have been recommended for the treatment of corneal ulcer and ocular surface disorders to reduced the progression of stromal ulcer and to minimize corneal scarring.

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Background: Hypertension is a globally important public health issue. It is a risk factor for various diseases like cardiovascular diseases, stroke, kidney failure and many other premature mortality and disability. To estimate the burden of hypertension and associated risk factorsObjectives: among the study subjects. A community based cross sectional study design was adopted. Total 327 subjects of age 30 years and aboveMethod: were included in the study, probability proportion to population size and simple random sampling was used for collection of data after getting informed consent in Chiraigaon block of Varanasi. Overall prevalence of hypertension was 32.4 % in our study. About 75% subjectsResults: were newly diagnosed hypertensive. High burden of undiagnosed hypertensive is present in rural area which needs to be addressedConclusion: with large scale community based study.