Non-ionic surfactant vesicular systems (niosomes) are structurally similar to lipid vesicles, differing only in the bilayer composition. Herein we report a unique method to generate reactive oxygen species (ROS) utilizing...

The ligand-to-metal charge transfer in gold nanoclusters gets influenced by the interacting lipid that regulates photoinduced electron transfer in the aqueous medium.

Ion-aided inclusion of protein-coated nanoparticles inside the liposomal membranes is frequently used in drug delivery. However, the stability of the liposomes depends heavily on the nature of the interaction. Herein, we have used a niosomal membrane made from a 1:1 Triton X-100 (TX-100)/cholesterol mixture to incorporate bovine serum albumin (BSA)-coated silver nanoclusters (AgNCs) to impart stability driven by the specific interaction between TX-100 and BSA. Such an assembly is found to be sensitive to external stimuli, such as temperature and UV radiation. This composite is used here to observe and analyze the dynamics of Forster resonance energy transfer (FRET) between the AgNCs and a coumarin dye (coumarin 6 or C6), the photoluminescence (PL) of which, otherwise, shows aggregationcaused quenching (ACQ). Moreover, the dynamics of FRET is considerably slowed down by the niosomal membrane inclusion, which helped us in obtaining the detail of the phenomenon. The quantitative and regulative stimuli-responsive analysis helped us in constructing a "FRET on−off" system and an energy antenna.

Daunomycin (DN) is a well-known chemotherapy drug frequently used in treating acute myeloid and lymphoblastic leukemia. It needs to be delivered to the therapeutic target by a delivering agent that beats the blood–brain barrier. DN is known to be specifically located at the membrane surface and scantly to the bilayer. Penetration of DN into the membrane bilayer depends on the molecular packing of the lipid. It does not travel promptly to the interior of the cells and needs a carrier to serve the purpose. Here, we have demonstrated, by fluorescence lifetime imaging spectroscopy (FLIM) and resonance energy transfer (RET) phenomenon, that ultrasmall graphene quantum dots (GQDs) can be internalized into the aqueous pool of giant unilamellar vesicles (GUVs) made from dipalmitoylphosphatidylcholine (DPPC) lipids, which, in turn, help in fast translocation of DN through the membrane without any delivery vehicle.

The unique chiral properties exhibited by nanoscale materials and their preferable interactions with the helicity of free-standing protein-based biopolymers offer a novel platform for developing spintronic applications. We investigated the chiroptical effect in charge transfer processes in a chiral carbon dot (C-Dot)-doped biopolymer, specifically a free-standing proteinbased film composed of bovine serum albumin (BSA). Here, we reveal a chiroptical effect in the charge transfer process, indicating spin selectivity of the charge carriers by measuring the circular dichroism spectra and by conducting an electrical study of the chiral C-dot-doped BSA film. To our knowledge, this is the first study to investigate chiral-selected electron transfer through a freestanding chiral C-Dot-doped protein-based film. Our results provide new insights into the chiral properties of materials and suggest potential applications in the development of chiral-sensitized bioelectronic devices, including the fabrication of chiral electrodes. These advancements in biopolymer-based chiral electronics could have important implications in biosensing, drug delivery, and other biomedical applications.