Objective: To evaluate the effects of calcium carbonate and calcium gluconate on acute and subacute inflammation, and to study their possible interactions with aspirin, verapamil and magnesium sulphate. Materials and Methods: Calcium carbonate in the dose of 10, 25, 50 mg/kg, calcium Department of Pharmacology and gluconate in the dose of 5, 10, 25, 50 mg/kg, and aspirin in the dose of 54, 200 mg/kg Pharmacotherapeutics, were administered orally in different groups of albino rats, to study their effect on J.N. Medical College, inflammation induced by carrageenan or a foreign body. Aspirin (54 mg/kg) was Nehru Nagar, administered either with calcium carbonate (10 mg/kg) or calcium gluconate (5 mg/kg) Belgaum-590 010. India to separate groups in order to study their interaction, especially with reference to gastric