Background: The study conducted a component analysis of the dynamics of the incidence of breast cancer (BC) in Karaganda region. Methods: Primary data were for registered patients with BC (ICD 10–C50) in Kazakhstan, Karaganda region the period of 2009-2018. Evaluation of changes in BC incidence in the population of Karaganda was performed using component analysis according to the methodological recommendations. Results: Overall, 4,391 new cases of BC and 1,202 deaths were recorded. The incidence rate increased from 44.4 (2009) to 72.7 in 2018 and the overall growth was 28.37 per 100,000 population of female, including due to the age structure – ∑ΔA=3.13, due to the risk of acquiring illness – ∑ΔR=22.69 and their combined effect – ∑ΔRA=2.56. The component analysis revealed that the increase in the number of patients with BC was mainly due to the growth of the population (ΔP=+3.7%), changes in its age structure (ΔA=+10.3%) and changes associated with the risk of acquiring illness (ΔR=+75.0%). The mortality rate in the region changed from 18.6 (2009) to 10.9 (2018) and tended to decrease. Conclusion: The role of the influence of demographic factors and the risk of acquiring illness on the formation of the number of patients and the incidence of BC was evaluated. In this region, these indicators were the highest. The implementation of the results of this study is recommended in management of anticancer activities for BC.

Breast cancer (BC) mortality analysis at the regional level is important not only for assessing the current epidemiological situation, but also contributes to a better understanding of factors that may affect mortality. Aim. The purpose of the study is to assess the spatial deaths from BC in Kazakhstan. Material and methods. Investigation was retrospective between 2009-2018 years. The materials were collected by statistics Committee by the Ministry of National Economy of the Republic of Kazakhstan concerning the deaths from BC (ICD-10-C50). A method of compiling a cartogram based on the determination of the standard deviation (σ) from the mean (x) was applied. Mortality rates calculated per 100,000 female population were used. Results and discussion. A spatial assessment of breast cancer mortality was presented based on the calculation of mortality rates: low up to 12.80/0000; average from 12.8 to 17.30/0000, and high – above 17.30/0000. It was established that the North Kazakhstan (18.20/0000), Akmola (18.90/0000), East Kazakhstan (20.30/0000) and Pavlodar (22.20/0000) regions, as well as the city of Almaty (21.70/0000) relate to regions with high mortality rates. Conclusion. Features of mortality from BC in the republic have been established, while a spatial assessment (cartogram) of mortality indicates regions with different mortality rates. The obtained data are recommended to be used for monitoring and evaluation of anti-cancer measures – BC screening. Keywords: mortality, breast cancer, cartogram, Kazakhstan.

About 3.15 million new cases of colorectal cancer (CRC) are predicted and it is expected that about 1.62 million human will die from this pathology, according to the forecasts of the International Agency for Research on Cancer in 2040. To this aim, an analysis studying studying the indicators of the oncological service for CRC also makes it possible to evaluate the ongoing anti-cancer measures in East Kazakhstan region. Aim. Evaluate some indicators of the oncological service at CRC in East Kazakhstan region in 2009 to 2018. Materials and methods. The research material was data from the Ministry of Health of the Republic of Kazakhstan – annual form No. 7 and 35 regarding CRC (ICD 10 – C18-21) for 2009-2018 in East Kazakhstan region – incidence, mortality, early diagnosis, neglect, morphological verification. A retrospective study using descriptive and analytical methods of biomedical statistics was used as the main method. Results and discussion. For 2009-2018, 3,661 new cases of CRC were registered in East Kazakhstan region for the first time. The incidence of CRC was 25.30/0000 and in dynamics tended to increase from 21.90/0000 (2009) to 25.70/0000 in 2018, the difference was statistically significant (t=1.99 and p=0.047). The mortality rate from CRC tended to decrease from 15.50/0000 to 14.70/0000 (p=0.591), and the average annual mortality rate from CRC was 15.60/0000. The indicators of early diagnosis (the proportion of patients with stage I-II) improved from 58.8% (2009) to 62.3% in 2018, and, accordingly, the indicators of the proportion of neglected patients significantly decreased with stage III (from 25.5% to 20.8%), while with stage IV (from 15.7% to 16.9%) there is a slight increase. The indicators of morphological verification in CRC improved from 90.5% to 98.6% during the studied years. Conclusion. An improvement in the indicators of morphological verification and early diagnosis of CRC was found. The obtained results are recommended to be used for monitoring anti-cancer measures in the region. Keywords: colorectal cancer, incidence, mortality, early diagnosis, neglect, morphological verification.

According to estimates from the International Agency for Research on Cancer (IARC) by 2040 the global burden is expected to grow to 3 million new breast cancer cases and 1 million cancer deaths of this cause. Studying the indicators of the oncological service for breast cancer allows us to identify and evaluate the effectiveness of mammological screening in Kazakhstan. Aim. Evaluate some indicators of the oncological service at breast cancer in Kazakhstan in 2009 to 2018. Material and methods. The research material was data from the Ministry of Health of the Republic of Kazakhstan - annual form No.7 and No.35 regarding breast cancer (ICD 10 C50) for 2009-2018. - morbidity, mortality, early diagnosis, neglect, morphological verification. A retrospective study using descriptive and analytical methods of biomedical statistics was used as the main method. Results and discussion. For 2009-2018, 40,199 new cases of breast cancer were registered in the republic for the first time and 12,971 women died from this disease. The average annual crude incidence rate of breast cancer was 45.4±1.40/0000 (95% CI=42.8-48.1) and increased in dynamics from 39.5±0.70/0000 (2009) to 49.6±0.70/0000 in 2018, the difference was statistically significant (t=10.2 and p=0.000). In dynamics, mortality rates from breast cancer tended to statistically significant (t=7.95 and p=0.000) decrease from 16.5±0.40/0000 (2009) to 12.0±0.40/0000 in 2018 year, and the average annual crude mortality rate from breast cancer was 14.8 0.50/0000 (95% CI=13.7-15.8). The indicators of early diagnosis (the proportion of patients with stage I-II) improved from 71.1% (2009) to 87.6% in 2018, the proportion of patients with stage III decreased (from 22.2% to 8.6 %) and stage IV (from 6.4% to 3.6%) for the studied years, i.e. neglect rates are declining. The indicators of morphological verification in breast cancer have always been high and over the studied years improved from 93.4% to 99.1%. Conclusion. An analysis of the indicators of the oncological service at breast cancer revealed an improvement in morphological verification and early diagnosis, a decrease in neglect and mortality rates, which is undoubtedly associated with ongoing anti-cancer measures in Kazakhstan, which a regularly mammological screening. Keywords: breast cancer, incidence, mortality, early diagnosis, neglect, morphological neglect.