One pot green synthesis and isolation of regioisomers of a library of DNA targeting anticancer Ru(ii)-p-cymene complexes to bringforth as cancer cell imaging as well as terminating agents.

We have introduced Amberlite IRA 402(OH) mediated green synthesis of benzothiazolyl quinoline based fluorescent scaffolds (6a-l) for cancer theranostic application.) demonstrated more or comparable cytotoxicity tocisplatin against all the tested cancer cell lines.Most of the synthesized compounds are 3-25 folds more selective in cancer cell line than normal fibroblast . It was also evident that compound 6 a (8-[2-(2benzothiazol-2-yl-phenoxy)-ethoxy]-quinoline) can be utilized as cancer theranostic agent since it has good quantum yield in water, significant cellular uptake, high potency and selectivity in all the cancer cell lines.

A series of ruthenium(ii)–arene-2-arylimidazophenanthroline based DNA targeting, cytoselective, hypoxia efficient and glutathione-resistant luminescent anticancer drugs have been developed which are also represented as HeLa cell imaging probes.

Ru(ii)–arene-2-heteroarylbenzoxazole complexes were synthesized and implemented for their biological evaluation.

Mitochondria targeting half-sandwich Iridium(iii)-Cp*-arylimidazophenanthroline complexes have been developed for MDA-MB-468 cell therapy and diagnosis.