Rationale: Draksharishta (DRK) is an Ayurvedic formulation approved by the "National formulary of Ayurvedic Medicine 2011", of Bangladesh. It is widely available in the Bangladeshi market as an effective preparation to treat lumbago, sciatia and arthritic pain of joints. But there are very scienti ic evidences available to support their common uses. Objectives: Our present studies make an attempt toward identifying probable antinociceptive and anti-in lammatory effect and its mechanisms of DRK. Findings: DRK, at three doses, (10 mL/kg, 20 mL/kg, and 40 mL/kg) showed no involvement of the CNS in antinociceptive activity of the test drug. Both Carrageenaninduced paw edema and acetic acid writhing tests gave signi icant results (P < 0.05), indicating possible peripheral analgesic and anti-in lammatory action. Formalin-induced paw-licking test showed that DRK had signi icant effect in suppressing in lammatory pain (P < 0.05) but not neurogenic pain. Conclusions: Hence our study shows anti-in lammatory and peripheral analgesic action for DRK.

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Kutajarishta (KTJ) is an Ayurvedic formulation approved by the "National formulary of Ayurvedic Medicine 2011", of Bangladesh. It is widely available in the Bangladeshi market as an effective preparation to treat lumbago, sciatia and arthritic pain of joints. Our present studies make an attempt toward identifying probable anti-nociceptive and anti-inflammatory mechanisms of KTJ. KTJ, at three doses, (10mL/kg, 20mL/kg, and 40mL/kg) showed no involvement of the CNS in anti-nociceptive activity in Hot plate test and Tail immersion test models. Carrageenan induced paw edema and acetic acid writhing tests both gave significant results (P ≤ 0.05), indicating possible peripheral analgesic and anti-inflammatory action. Formalin induced paw-licking test showed that KTJ had significant effect in suppressing inflammatory pain (P≤0.05) but not neurogenic pain. Hence our study shows anti-inflammatory and peripheral analgesic action for KTJ.