Investigation of the central and peripheral analgesic and anti-inflammatory activity of Draksharishta an Indian Ayurvedic formulation

Kabir, Ashraf-ul; Samad, Mehdi Bin; D’Costa, Ninadh Malrina; Hannan, Juardar Mohammad

doi:10.4103/0976-0105.105335

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…Based on these findings, we inferred that the anti-inflammation of Malyngamide F may be mediated by suppressing the production of IL-6 and TNF- α . On the other hand, convincing evidence has indicated that PGE-2 can cause abdominal constriction, and it is mostly responsible for causing inflammatory pain [ 35 , 36 ]. Several flavonoids have been demonstrated to produce analgesic action through suppression of PGE-2 synthesis [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation

Zhang²,

Zhao

2021

Pain Research and Management

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Objective. Inflammation and pain are involved in the pathophysiology of various clinical conditions. This investigation aims to probe the analgesic and anti-inflammatory activity of Maltoamide F. Methods. The possible toxicity of Maltoamide F was evaluated by an acute toxicity test. To assess the anti-inflammatory and antinociceptive effects of Maltoamide F on rats, the models of carrageenan-caused paw edema, xylene-induced ear edema, arachidonic-acid- (AA-) induced ear edema, formalin-caused plantar edema, and cotton-pellet-induced granuloma were established. Levels of TNF-α, PGE-2, and IL-6 were detected by enzyme-linked immunosorbent assay (ELISA). Results. Maltoamide F was safe at oral doses of 1–10 mg/kg for rats. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) notably reduced carrageenan-induced edema percentage of paws in rats and decreased levels of PGE-2, IL-6, and TNF-α in homogenates of foot tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced levels of PGE-2, IL-6, and TNF-α in foot tissues of formalin-induced rats. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) repressed AA-induced increase of ear thickness in rats and reduced levels of PGE-2, IL-6, and TNF-α in homogenates of ear tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced xylene-induced weight of ear edema in rats and reduced levels of PGE-2, IL-6, and TNF-α in homogenates of ear tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced levels of PGE-2, IL-6, and TNF-α in homogenates of cotton ball granuloma of cotton-pellet-induced rats. Conclusions. Maltoamide F possessed anti-inflammatory and analgesic activity in inflammatory models of rats.

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Section: Discussionmentioning

confidence: 99%

Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation

Zhang²,

Zhao

2021

Pain Research and Management

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“…The formalin test was carried out as described previously. [ 12 16 ] Each animal was assigned and acclimatized to one of 20 formalin test chambers (a perspex chamber 15 cm × 15 cm × 15 cm) for 30 min before formalin injection. Male mice were then pretreated with vehicle (10 ml/kg of 0.9% NaCl, i.p), XA (10–100 mg/kg, p.o.)…”

Section: Methodsmentioning

confidence: 99%

An isobolographic analysis of the antinociceptive effect of xylopic acid in combination with morphine or diclofenac

Woode

Ameyaw

Abotsi

et al. 2015

J Basic Clin Pharma

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Background:A common practice of managing pain globally is the combination of analgesics and this is aimed at facilitating patient compliance, simplifying prescription, and improving efficacy without increasing adverse effects. Fruit extracts of Xylopia aethiopica are used traditionally in the management of pain disorders and xylopic acid (XA) present in the fruit extract have been shown to possess analgesic properties in animals. There is the likelihood of concomitant use of XA and the commonly used analgesics in traditional settings. This study, therefore, evaluated the pharmacologic interaction between XA/morphine and xylopic/diclofenac combinations.Methods:The formalin test and acetic acid writhing test were used to study the antinociceptive activity of XA, morphine, and diclofenac. The isobolographic analysis was used to study the antinociceptive interactions between XA co-administered with morphine or diclofenac.Results:Results obtained revealed that XA (10–100 mg/kg), morphine (1–10 mg/kg), and diclofenac (1–10 mg/kg) produced dose-related antinociception with different potencies in the formalin and acetic acid writhing tests. Isobolographic analysis of XA/morphine and XA/diclofenac combinations revealed potentiation of their antinociceptive effects. The degree of potentiation calculated as interaction index showed synergism for both combinations in all the nociceptive tests.Conclusion:In conclusion, the present study demonstrated synergism for the co-administration of XA with morphine or diclofenac.

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Synthesis, cyclooxygenase inhibition, and anti-inflammatory evaluation of novel diarylheterocycles with a central pyrazole, pyrazoline, or pyridine ring

et al. 2015

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Investigation of the central and peripheral analgesic and anti-inflammatory activity of Draksharishta an Indian Ayurvedic formulation

Cited by 5 publications

References 13 publications

Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation

Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation

An isobolographic analysis of the antinociceptive effect of xylopic acid in combination with morphine or diclofenac

Synthesis, cyclooxygenase inhibition, and anti-inflammatory evaluation of novel diarylheterocycles with a central pyrazole, pyrazoline, or pyridine ring

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