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Aims: This study aims to assess the clinicopathological features, treatment, recurrence pattern, survival, and prognostic factors in patients with endometrial carcinoma (EC). Materials and Methods: This was a retrospective study of 64 patients with EC who were diagnosed and treated at our institute from January 2010 to December 2013 and were followed till December end 2019. Survival analysis was done using Kaplan–Meier estimates and significance between curves by using the log-rank test. Results: The mean age of diagnosis was 60 years. The most common complaint was vaginal bleeding (75%). More than half of the patients (52.6%) had high body mass index (BMI). The majority of patients underwent surgery (90.7%) and had the early-stage disease (Stage I in 82.9%). During a median follow-up of 79 months (range: 4–100 months), 18.8% of patients experienced recurrence and vaginal vault (33.3%) was the most common site for recurrence. The 5-year disease-free survival was 83% and the 5-year overall survival was 84.7%. Elderly age, high BMI, advanced disease stage, more than 50% of myometrial invasion, nonendometrioid histology, Grade II and Grade III tumors, lymphovascular space invasion, and lymph node involvement adversely affected long-term survival. Conclusion: EC is mainly a disease of postmenopausal women, and most of them are diagnosed at an early stage and have good survival outcomes.

Objective: The objective of this study was to find the profile of childhood cancers in the Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, India, from 2010 to 2019. Materials and Methods: It was a retrospective study where medical records of children with cancer that was registered in regional cancer center SKIMS, Srinagar, from January 2010 to December 2019, aged 0–14 years diagnosed using histological or cytological examinations were reviewed to gather data on the prevalence and pattern of tumors according to age, sex, and rural and urban distribution. Results: There were 38,962 new confirmed cases registered in the regional cancer center at SKIMS, Srinagar, during these 10 years. Among which 1036 were below 15 years of age. An average of 103 cases attended per year. Overall pediatric tumors were 2.66% of total cancers. The frequency of cancer was found to be higher among boys (57.9%) than girls (42.1%) with a ratio of 1.37:1. The majority of the children were from rural areas (84.9%) compared to (15.1%) from urban areas. The results showed that leukemia (36.6%), lymphoma (19.8%), and bone tumors (9.3%) were the commonly found childhood cancers among the children attended at SKIMS, Srinagar, during these 10 years. Other less commonly found tumors were central nervous system tumors (6.7%), Wilms' tumor (4.1%), retinoblastoma (3.7%), and cancer of unknown primary with secondaries (1.5%). Conclusions: Leukemia, lymphoma, and bone tumors were the most common malignancies reported in the children treated at our cancer center.

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Background: In clinical practice, the management of cancer-related anorexia/cachexia syndrome (CACS) is a great challenge. We conducted an observational study to find the effectiveness and safety of megestrol acetate (MA) for the treatment of CACS. Patients and Methods: One hundred patients of advanced cancer were randomly assigned in the study. Patients received MA 160 mg/oral twice daily. The duration of treatment was 8 weeks. Results: The analysis of the study group demonstrated a statistically significant increase from baseline in body weight (P ≤ 0.01), quality of life (P = 0.02), appetite (P = 0.01), and the Eastern Cooperative Oncology Group performance status (P = 0.03). Conclusion: We concluded that MA is effective and safe in the treatment of CACS.