Nasopharyngeal carcinoma (NPC) is a rare malignancy in Kashmir with distinct pattern, hence we planned to study its clinicodemographic and survival profile. Kashmir has unique lifestyle and dietary habits which may be the source of carcinogenic compounds, most likely implicated in causation of NPC. A total of 148 patients of NPC registered from January 2000 to December 2014 were analyzed. The Mean ± SD age was 45.15 ± 17.092 years (range 11-85 years). The males were 72.3 % (N = 107) with male: female ratio of 2.61:1. Most of the patients were from rural area 81.90 % (N = 95) and non-smokers were 53.44 % (N = 62). Neck swelling was commonest presentation. WHO Type III NPC was commonest histopathological diagnosis 65.3 % (N = 92). Stage IV 36.1 % (N = 51) was commonest stage followed by stage III was 32 % (N = 46). Majority of the patients of NPC received CCRT 68.7 % (N = 78) followed by SCRT 13 % (N = 15) and Induction ? CCRT 13 % (N = 15). The overall mean survival of NPC was 49.56 months. There was no significant correlation of age, gender, smoking, histopathology and treatment on the overall survival. However the stage was the only strong predictor of overall survival. Also the patients with intracranial extension had low survival which is turn depicts the advanced stage of disease. NPC survival is directly related to the stage of the disease irrespective of the treatment modality received. The negative EBV status in our patients implies that there are other risk factors involved in the causation of NPC for which further studies are needed to establish the etiological insult.
The female breast cancer survivors failed to improve their body image, sexual functioning, and sexual enjoyment scales but did well in other BR23 scales. Besides the family and spousal/marital support these patients got closer to their religion which has been seen to influence their psychosocial well-being optimistically and need further studies to establish the role of religious practices/beliefs.
Renal cell carcinoma constitutes 3% of all adult malignancies and often presents insidiously with vague abdominal symptoms. It has a variable natural course and metastatic involvement of the lung, lymph nodes, liver, bone, adrenal glands, kidney, brain, heart, spleen, intestine, and skin is usually seen in descending order of frequency. However, the duodenum is an uncommon site for metastasis from renal cell carcinoma. Consequently, diagnosis and an appropriate treatment are often delayed because of rarity of this type of metastatic involvement. Thorough endoscopic evaluation of the upper small intestine and a high index of suspicion are vital for correct diagnosis and appropriate management of this type of metastatic involvement.
Case PresentationRT-500/02, a 52 year old Kashmiri (Asian) male, an exsmoker, presented with complains of intermittent painless hematuria of 4 months duration. There was no history of fever, spasmodic pain, breathlessness or bleeding tendencies from other sites. His general physical examination was normal and there was no lymphadenopathy. His chest, cardiovascular and abdominal examination did not reveal any abnormality. On investigations, his haemogram, biochemical parameters and X-ray of chest were normal. His urine
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